Citation Top 5 （by Scopus, as of March 4, 2024）

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1 Sikder MM, Uyama T, Sasaki S, Kawai K, Araki N, Ueda N, PLAAT1 expression triggers fragmentation of mitochondria in an enzyme activity-dependent manner. J Biochem. 175:101-113, 2024

2 宇山　徹，佐々木　すみれ，上田　夏生, N-アシルエタノールアミンの生合成機構と生理機能．ビタミン 98：8–17, 2024

3 エス エム カレドゥル ラハマン，佐々木 すみれ,　宇山 徹，ザヒル フセイン， モハメッド マムン シクダル，財賀 大行，星野 真理，太田 健一,　三木 寿美 , 星野 克明, 上野 正樹，村上 誠，上田 夏生,　マウスにおける phospholipase A and acyltransferase 1(PLAAT1)の 欠損は高脂肪食誘導性の脂肪肝を改善させる.　ビタミン 98：65–69, 2024

２０２３

1 Ayaki S, Mii T, Matsuno K, Tokuyama T, Tokuyama T, Tokuyama T, Uyama T, Ueda N, β-1,4-Galactan suppresses lipid synthesis in sebaceous gland cells via TLR4. J Biochem 173:85-94, 2023

2 Kittikulsuth W, Nakano D, Kitada K, Uyama T, Ueda N, Asano E, Okano K, Matsuda Y, Nishiyama A. Vasoactive intestinal peptide blockade suppresses tumor growth by regulating macrophage polarization and function in CT26 tumor-bearing mice. Sci Rep 13:927, 2023

3 Uyama T, Ueda N, Assay of NAT activity. Methods Mol Biol 2576:213-224, 2023

4  Tsuboi K, Ueda N, Assay of NAAA activity. Methods Mol Biol 2576:261-274, 2023

5  Tevosian M, Todorov H, Lomazzo E, Bindila L, Ueda N, Bassetti D, Warm D, Kirischuk S, Luhmann HJ, Gerber S, Lutz B, NAPE-PLD deletion in stress-TRAPed neurons results in an anxiogenic phenotype. Transl Psychiatry 13:152, 2023

6  Maccarrone M, Di Marzo V, Gertsch J, Grether U, Howlett AC, Hua T, Makriyannis A, Piomelli D, Ueda N, van der Stelt M, Goods and bads of endocannabinoid system as a therapeutic target: Lessons learned after 30 years. Pharmacol Rev 2023 May 10. doi: 10.1124/pharmrev.122.000600.

7  GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator. Kitakaze K, Ali H, Kimoto R, Takenouchi Y, Ishimaru H, Yamashita A, Ueda N, Tanaka T, Okamoto Y, Tsuboi K, Commun Biol 6(1):524, 2023

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1 Rahman SMK, Hussain Z, Morito K, Takahashi N, Sikder MM, Tanaka T, Ohta K, Ueno M, Takahashi H, Yamamoto T, Murakami M, Uyama T, Ueda N, Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A₂ε in an ex vivo murine model of brain ischemia. Biochim Biophys Acta - Mol Cell Biol Lipids 1867:159222,2022 

2 Watanabe S, Nihongaki Y, Itoh K, Uyama T, Toda S, Watanabe S, Inoue T, Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases. Nat Commun 13:4413, 2022 

２０２１

1 Guo Y, Uyama T, Rahman K, Sikder MM, Hussain Z, Tsuboi K, Miyake M, Ueda N, Involvement of γ isoform of cPLA2in the biosynthesis of bioactive N-acylethanolamines. Molecules 26 (17): 5213, 2021

2 Rahman SMK, Uyama T, Hussain Z, Ueda N, Roles of endocannabinoids and endocannabinoid-like molecules in energy homeostasis and metabolic regulation: a nutritional perspective. Annu Rev Nutr 41:177-202, 2021

3 Tsuboi K, Tai T, Yamashita R, Ali H, Watanabe T, Uyama T, Okamoto Y, Kitakaze K, Takenouchi Y, Go S, Rahman IAS, Houchi H, Tanaka T, Okamoto Y, Tokumura A, Matsuda J, Ueda N, Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines. Biochim Biophys Acta - Mol Cell Biol Lipids 1866, 158972. doi: 10.1016/j.bbalip.2021.158972. Epub 2021 May 24.

4 Tsuboi K, Uyama T, Ueda N, Chapter 7 Inhibition of NAPE-PLD Activity by Natural Compounds and Synthetic Drugs, and Its Biological Relevance. New Tools to Interrogate Endocannabinoid Signalling: From Natural Compounds to Synthetic Drugs (Ed., Mauro Maccarrone), RSC Drug Discovery Series 2021-January (76), pp. 301-336

5 上田夏生, 3.3.1はじめに（概要）, 3.3不飽和脂肪酸．ビタミン・バイオファクター総合事典（日本ビタミン学会編）朝倉書店, 東京, 322, 2021

6 宇山徹, 3.3.2化学・生化学（構造, 化学的性質, 代謝）, 3.3不飽和脂肪酸．ビタミン・バイオファクター総合事典（日本ビタミン学会編）朝倉書店, 東京, 323-327, 2021

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1 宇山徹，上田夏生，明らかになり始めた生理活性脂質N-アシルエタノールアミンの生合成機構．N-アシル転移酵素の構造と機能．化学と生物58:599-605, 2020

2 坪井一人，宇山徹，上田夏生，N-アシルエタノールアミンの機能と生合成機構．生化学 92:666-679, 2020

3 Yamamoto K, Ueda N, In Memoriam: Shozo Yamamoto (1933-2020). J Lipid Res 61:1305-1306, 2020

4 上田夏生，山本尚三先生を偲ぶ．生化学 92(3):i-ii, 2020

5 上田夏生，山本尚三名誉会員のご逝去を悼む．ビタミン 94(7), 2020

6 上田夏生，必須脂肪酸と脂質メディエーター．ビタミン 94:190-196, 2020

２０１９

1 Binte Mustafiz SS, Uyama T, Morito K, Takahashi N, Kawai K, Hussain Z, Tsuboi K, Araki N, Yamamoto K, Tanaka T, Ueda N, Intracellular Ca²⁺-dependent formation of N-acyl-phosphatidylethanolamines by human cytosolic phospholipase A2ε. Biochim Biophys Acta-Mol Cell Biol Lipids 1864, doi: 10.1016/j.bbalip.2019.158515

2 Mustafiz SSB, Uyama T, Hussain Z, Kawai K, Tsuboi K, Araki N, Ueda N, The role of intracellular anionic phospholipids in the production of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ɛ. J Biochem 165:343-352, 2019

3 宇山徹，上田夏生，アナンダミドとN-アシルエタノールアミンの代謝と疾患制御．医学のあゆみ 269:1015-1022, 2019

4 上田夏生，脂質メディエーター N -アシルエタノールアミンの代謝に関する酵素学的研究．ビタミン 93:103-114, 2019

２０１８

1 Tsuboi K, Uyama T, Okamoto Y, Ueda N, Endocannabinoids and related N-acylethanolamines: biological activities and metabolism. Inflamm Regen 38:28, 2018

2 Hussain Z, Uyama T, Kawai K, Mustafiz SSB, Tsuboi K, Araki N, Ueda N, Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca²⁺-dependent N-acyltransferase.　Biochim Biophys Acta-Mol Cell Biol Lipids 1863:493-502, 2018

3 Binte Mustafiz SS, Uyama T, Hussain Z, Tsuboi K, Ueda N, The biosynthetic pathways of N-acylethanolamines in mammals. eLS, John Wiley & Sons, Ltd, 2018. DOI: 10.1002/9780470015902.a0027711

4 宇山徹，上田夏生，PLAAT(PLA2G16)ファミリー．医学のあゆみ 264:171-176, 2018

２０１７

1 Hussain Z, Uyama T, Tsuboi K, Ueda N, Mammalian enzymes responsible for the biosynthesis of N-acylethanolamines. Biochim Biophys Acta-Mol Cell Biol Lipids 1862:1546-1561, 2017

2 Uyama T, Tsuboi K, Ueda N, An involvement of phospholipase A/acyltransferase family proteins in peroxisome regulation and plasmalogen metabolism. FEBS Lett 591:2745-2760, 2017

3 Inoue M, Tsuboi K, Okamoto Y, Hidaka M, Uyama T, Tsutsumi T, Tanaka T, Ueda N, Tokumura A, Peripheral tissue levels and molecular species compositions of N-acyl-phosphatidylethanolamine and its metabolites in mice lacking N-acyl-phosphatidylethanolamine-specific phospholipase D. J Biochem 162:449-458, 2017

4 Sousa-Valente J, Varga A, Torres Perez JV, Jenes A, Wahba J, Mackie K, Cravatt B, Ueda N, Tsuboi K, Santha P, Jancso G, Tailor H, Avelino A, Nagy I, Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium-sensitive N-arachydonoylethanolamine-synthesizing enzyme and related molecules in rat primary sensory neurons. J Comp Neurol 525:1778-1796, 2017

5 坪井一人, 宇山徹，上田夏生，グリセロホスホジエステラーゼ・ファミリーによるN-アシルエタノールアミンおよびリゾホスファチジン酸の生成．ビタミン 91:489-496, 2017

6 上田夏生，新井洋由，はじめに（特集：ここまで明らかになったω３脂肪酸）．ビタミン 91:529-530, 2017

２０１６

1 Hussain Z, Uyama T, Kawai K, Rahman IA, Tsuboi K, Araki N, Ueda N, Comparative analyses of isoforms of the calcium-independent phosphatidylethanolamine N-acyltransferase PLAAT-1 in humans and mice. J Lipid Res 57:2051-2060, 2016

2 Sakura Y, Tsuboi K, Uyama T, Zhang X, Taoka R, Sugimoto M, Kakehi Y, Ueda N A quantitative study on splice variants of N-acylethanolamine acid amidase in human prostate cancer cells and other cells. Biochim Biophys Acta-Mol Cell Biol Lipids 1861:1951-1958, 2016

3 Rahman IAS, Tsuboi K, Hussain Z, Yamashita R, Okamoto Y, Uyama T, Yamazaki N, Tanaka T, Tokumura A, Ueda N, Calcium-dependent generation of N-acylethanolamines and lysophosphatidic acids by glycerophosphodiesterase GDE7. Biochim Biophys Acta-Mol Cell Biol Lipids 1861:1881-1892, 2016

4 Uyama T, Ueda N, Assay of NAT activity. Methods Mol Biol 1412, Endocannabinoid Signaling: Methods and Protocols (Maccarrone M, ed) Humana Press, 112-122, 2016 (ISBN: 978-1-4939-3537-6)

5 Tsuboi K, Ueda N, Assay of NAAA activity. Methods Mol Biol 1412, Endocannabinoid Signaling: Methods and Protocols (Maccarrone M, ed) Humana Press, 137-148, 2016 (ISBN: 978-1-4939-3537-6)

6 坪井一人，N-アシルエタノールアミンとリゾホスファチジン酸の生合成に関わる新規リゾホスホリパーゼD型酵素．生化学 88:240-243, 2016

7 宇山徹，渡邊政博, 坪井一人, 上田夏生，明らかになり始めた新規脂質代謝酵素群phospholipase A/acyltransferase (PLAAT) familyの生理機能．ビタミン 90:379-389, 2016

２０１５

1 Uyama T, Kawai K, Kono N, Watanabe M, Tsuboi K, Inoue T, Araki N, Arai H, Ueda N, Interaction of phospholipase A/acyltransferase-3 with Pex19p: a possible involvement in the downregulation of peroxisomes. J Biol Chem 290:17520-17534, 2015

2 Tsuboi K, Okamoto Y, Rahman IAS, Uyama T, Inoue T, Tokumura A, Ueda N, Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a possible involvement in bioactive N-acylethanolamine biosynthesis. Biochim Biophys Acta - Mol Cell Biol Lipids 1851:537-548, 2015

3 宇山徹，ホスホリパーゼA／アシルトランスフェラーゼ-3を介したペルオキシソームの制御機構．生化学 87:633-635, 2015

4 宇山徹，上田夏生，新規脂質代謝酵素群 PLAAT ファミリータンパク質の生理機能解析．BIO Clinica 30:89-95, 2015

5 坪井一人，上田夏生，エンドカンナビノイド．疾患モデルの作製と利用－脂質代謝異常と関連疾患<<下巻>>（尾池雄一，佐々木雄彦，村上　誠，矢作直也編）エル・アイ・シー社，東京，236-248, 2015

２０１４

1 Rahman IAS, Tsuboi K, Uyama T, Ueda N, New players in the fatty acyl ethanolamide metabolism. Pharmacol Res 86:1-10, 2014

2 Ueda N, Tsuboi K, Uyama T, CHAPTER 8 Metabolic Enzymes for Endocannabinoids and Endocannabinoid-Like Mediators. The Endocannabinoidome: The World of Endocannabinoids and Related Mediators (Di Marzo V, Wang J, eds) Elsevier, pp. 111-135, 2015 (ISBN: 978-0-12-420126-2)

3 宇山徹，上田夏生，アナンダミドと関連N-アシルエタノールアミン．医学のあゆみ 248:1003-1008, 2014

２０１３

1 Uyama T, Inoue M, Okamoto Y, Shinohara N, Tai T, Tsuboi K, Inoue T, Tokumura A, Ueda N, Involvement of phospholipase A/acyltransferase-1 in N-acylphosphatidylethanolamine generation. Biochim Biophys Acta - Mol Cell Biol Lipids 1831:1690-1701, 2013

2 Ueda N, Tsuboi K, Uyama T, Metabolism of endocannabinoids and related N-acylethanolamines: Canonical and alternative pathways, FEBS J 280:1874-1894, 2013

3 Tsuboi K, Ikematsu N, Uyama T, Deutsch D.G, Tokumura A, Ueda N, Biosynthetic pathways of bioactive N-acylethanolamines in brain. CNS Neurol Disord - Drug Targets 12:7-16, 2013

4 坪井一人, 岡本安雄, 池松夏紀, 井上愛美, 清水嘉文, 宇山徹, 王俊, Dale G. Deutsch, Matthew P. Burns, Nadine M. Ulloa, 徳村彰, 上田夏生, N-アシルエタノールアミンプラスマローゲンからのN-アシルホスファチジルエタノールアミン水解ホスホリパーゼD依存的および非依存的経路を介したN-アシルエタノールアミンの生合成．ビタミン 87:267-270, 2013

２０１２

1 Uyama T, Ikematsu N, Inoue M, Shinohara N, Jin X-H, Tsuboi K, Tonai T, Tokumura A, Ueda N, Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. J Biol Chem 287:31905-31919, 2012

2 Ueda N, Tsuboi K, Preview: discrimination between two endocannabinoids. Chem Biol 19:545-547, 2012

3 Yamano Y, Tsuboi K, Hozaki Y, Takahashi K, Jin X-H, Ueda N, Wada A, Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase. Bioorg Med Chem 20:3658-3665, 2012

4 Kallendrusch S, Hobusch C, Ehrlich A, Ziebell S, Ueda N, Geisslinger G, Koch M, Dehghani F, Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections. PLoS ONE 7:e33537, 2012

5 Tai T, Tsuboi K, Uyama T, Masuda K, Cravatt BF, Houchi H, Ueda N, Endogenous molecules stimulating N-acylethanolamine-hydrolyzing acid amidase (NAAA). ACS Chem Neurosci 3:379-385, 2012

6 Uyama T, Ichi I, Kono N, Inoue A, Tsuboi K, Jin X-H, Araki N, Aoki J, Arai H, Ueda N, Regulation of peroxisomal lipid metabolism by catalytic activity of tumor suppressor H-rev107. J Biol Chem 287:2706-2718, 2012

２０１１

1 Shinohara N, Uyama T, Jin X-H, Tsuboi K, Tonai T, Houchi H, Ueda N, Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes. J Lipid Res 52:1927-1935, 2011

2 Tsuboi K, Okamoto Y, Ikematsu N, Inoue M, Shimizu Y, Uyama T, Wang J, Deutsch DG, Burns MP, Ulloa NM, Tokumura A, Ueda N, Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. Biochim Biophys Acta - Mol Cell Biol Lipids 1811:565-577, 2011

3 Wellner N, Tsuboi K, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch DG, Ueda N, Hansen HS, Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice. Biochim Biophys Acta - Mol Cell Biol Lipids 1811:508-512, 2011

4 Ueda N, Tsuboi K, Uyama T, Ohnishi T, Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol. BioFactors 37:1-7, 2011

5 上田夏生，坪井一人，宇山徹，食欲抑制メディエーターとしてのオレオイルエタノールアミド．ビタミン 85:604-607, 2011

6 坪井一人，上田夏生，脂質メディエーターとして機能するN-アシルエタノールアミンの分解酵素とその阻害薬．日本薬理学雑誌 (Folia Pharmacol. Jpn.) 138:8-12, 2011

7 坪井一人，宇山徹，上田夏生，三本鎖のリン脂質N-アシルホスファチジルエタノールアミンの動物組織における代謝．生化学 83:485-494, 2011

２０１０

1 Ueda N, Tsuboi K, Uyama T, Enzymological studies on the biosynthesis of N-acylethanolamines. Biochim Biophys Acta - Mol Cell Biol Lipids 1801:1274-1285, 2010

2 Ueda N, Tsuboi K, Uyama T, N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA). Prog Lipid Res 49:299-315, 2010

3 Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D'Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V, Protective role of palmitoylethanolamide in contact allergic dermatitis. Allergy 65:698-711, 2010

4 上田夏生, その他のアラキドン酸含有リン脂質由来のメディエーター．ビタミン総合事典（日本ビタミン学会編）朝倉書店, 東京, 479-482, 2010

２００９

1 Jin X-H, Uyama T, Wang J, Okamoto Y, Tonai T, Ueda N, cDNA cloning and characterization of human and mouse Ca²⁺-independent phosphatidylethanolamine N-acyltransferases. Biochim Biophys Acta - Mol Cell Biol Lipids 1791:32-38, 2009

2 Shiratsuchi A, Ichiki M, Okamoto Y, Ueda N, Sugimoto N, Takuwa Y, Nakanishi Y, Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc42. J Biochem 145:43-50, 2009

3 Uyama T, Morishita J, Jin X-H, Okamoto Y, Tsuboi K, Ueda N, The tumor suppressor gene H-Rev107 functions as a novel Ca²⁺-independent cytosolic phospholipase A_1/2 of the thiol hydrolase-type. J Lipid Res 50:685-693, 2009

4 Uyama T, Jin X-H, Tsuboi K, Tonai T, Ueda N, Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. Biochim Biophys Acta - Mol Cell Biol Lipids 1791:1114-1124, 2009

5 Wang J, Ueda N, Biology of endocannabinoid synthesis system. Prostaglandins Other Lipid Mediat 89:112-119, 2009

6 Okamoto Y, Tsuboi K, Ueda N, Enzymatic formation of anandamide. Vitam Horm 81:1-24, 2009

２００８

1 Wang J, Zhao L-Y, Uyama T, Tsuboi K, Wu X-X, Kakehi Y, Ueda N, Expression and secretion of N-acylethanolamine-hydrolyzing acid amidase in human prostate cancer cells. J Biochem 144:685-690, 2008

2 Wang J, Zhao L-Y, Uyama T, Tsuboi K, Tonai T, Ueda N, Amino acid residues crucial in pH regulation and proteolytic activation of N-acylethanolamine-hydrolyzing acid amidase. Biochim Biophys Acta - Mol Cell Biol Lipids 1781:710-717, 2008

3 Placzek EA, Okamoto Y, Ueda N, Barker EL, Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. Neuropharmacology 55:1095-1104, 2008

4 Placzek EA, Okamoto Y, Ueda N, Barker EL, Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. J Neurochem 107:987-1000, 2008

5 Iwanaga Y, Ueno M, Ueki M, Huang C-L, Tomita S, Okamoto Y, Ogawa T, Ueda N, Maekawa N, Sakamoto H, The expression of osteopontin is increased in vessels with blood-brain barrier impairment. Neuropath Appl Neurobiol 34:145-154, 2008

6 Cristino L, Starowicz K, De Petrocellis L, Morishita J, Ueda N, Guglielmotti V, Di Marzo V, Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain. Neuroscience 151:955-968, 2008

7 Wang J, Okamoto Y, Tsuboi K, Ueda N, The stimulatory effect of phosphatidylethanolamine on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD). Neuropharmacology 54:8-15, 2008

8 Wang J, Ueda N, Role of the endocannabinoid system in metabolic control. Curr Opin Nephrol Hypertens 17:1-10, 2008

9 宇山徹，上田夏生，エンドカンナビノイド：生理機能、代謝、および医薬品開発．分子心血管病 9:610-616, 2008

２００７

1 Okamoto Y, Wang J, Morishita J, Ueda N, Biosynthetic pathways of the endocannabinoid anandamide. Chem Biodivers 4:1842-1857, 2007

2 Jin X-H, Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N, Discovery and characterization of a Ca²⁺-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. J Biol Chem 282:3614-3623, 2007

3 Tsuboi K, Zhao L-Y, Okamoto Y, Araki N, Ueno M, Sakamoto H, Ueda N, Predominant expression of N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies. Biochim Biophys Acta - Mol Cell Biol Lipids, 1771:623-632, 2007

4 Zhao L-Y, Tsuboi K, Okamoto Y, Nagahata S, Ueda N, Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism. Biochim Biophys Acta - Mol Cell Biol Lipids, 1771:1397-1405, 2007

5 Tsuboi K, Molecular characterization of a novel lysosomal enzyme degrading the anti-inflammatory lipid mediator N-acylethanolamine. Inflammation and Regeneration 27:18-27, 2007

6 Tsuboi K, Takezaki N, Ueda N, The N-acylethanolamine-hydrolyzing acid amidase (NAAA). Chem Biodivers 4:1914-1925, 2007

7 坪井一人，上田夏生，エンドカンナビノイドの生理的機能と生合成・分解. 細胞工学 26:1264-1268, 2007

２００６

1 Ding J, Tsuboi K, Hoshikawa H, Goto R, Mori N, Katsukawa M, Hiraki E, Yamamoto S, Abe M, Ueda N, Cyclooxygenase isozymes are expressed in human myeloma cells but not involved in anti-proliferative effect of cyclooxygenase inhibitors. Mol Carcinog 45:250-259, 2006

2 Wang J, Okamoto Y, Morishita J, Tsuboi K, Miyatake A, Ueda N, Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-β-lactamase family. J Biol Chem 281:12325-12335, 2006

２００５

1 Tsuboi K, Sun Y-X, Okamoto Y, Araki N, Tonai T, Ueda N, Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. J Biol Chem 280:11082-11092, 2005

2 Okamoto Y, Morishita J, Wang J, Schmid PC, Krebsbach RJ, Schmid HHO, Ueda N, Mammalian cells stably overexpressing N-acylphosphatidylethanolamine-hydrolyzing phospholipase D exhibit significantly decreased levels of N-acylphosphatidylethanolamines. Biochem J 389:241-247, 2005

3 Morishita J, Okamoto Y, Tsuboi K, Ueno M, Sakamoto H, Maekawa N, Ueda N, Regional distribution and age-dependent expression of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D in rat brain. J Neurochem 94:753-762, 2005

4 Guo Y, Wang H, Okamoto Y, Ueda N, Kingsley PJ, Marnett LJ, Schmid HHO, Das SK, Dey SK, N-Acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. J Biol Chem 280:23429-23432, 2005

5 Sun Y-X, Tsuboi K, Zhao L-Y, Okamoto Y, Lambert DM, Ueda N, Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages. Biochim Biophys Acta 1736:211-220, 2005

6 Yamamoto S, Katsukawa M, Nakano A, Hiraki E, Nishimura K, Jisaka M, Yokota K, Ueda N, Arachidonate 12-lipoxygenases with reference to their selective inhibitors. Biochem Biophys Res Commun 338:122-127, 2005

7 Ueda N, Tsuboi K, Lambert DM, A second N-acylethanolamine hydrolase in mammalian tissues. Neuropharmacology 48:1079-1085, 2005

8 Ueda N, Okamoto Y, Tsuboi K, Endocannabinoid-related enzymes as drug targets with special reference to N-acylphosphatidylethanolamine-hydrolyzing phospholipase D. Curr Med Chem 12:1413-1422, 2005

9 Ueda N, Okamoto Y, Morishita J, N-Acylphosphatidylethanolamine-hydrolyzing phospholipase D: a novel enzyme of the β-lactamase fold family releasing anandamide and other N-acylethanolamines. Life Sci 77:1750-1758, 2005

10 上田夏生，内因性マリファナ様物質の代謝と情報伝達. オレオサイエンス 5:73-81, 2005

11 上田夏生，坪井一人，アナンダミドの合成酵素と分解酵素. 生化学 77:1505-1509, 2005

２００４

1 Tsuboi K, Hilligsmann C, Vandevoorde S, Lambert DM, Ueda N, N-Cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase. Biochem J 379:99-106, 2004

2 Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N, Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem 279:5298-5305, 2004

3 Sun Y-X, Tsuboi K, Okamoto Y, Tonai T, Murakami M, Kudo I, Ueda N, Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A₂ and lysophospholipase D. Biochem J 380:749-756, 2004

4 Ueda N, Deutsch DG, Biosynthesis and degradation of anandamide, an endogenous ligand of cannabinoid receptors. The Eicosanoids (Curtis-Prior P, ed) John Wiley & Sons, London, pp. 179-187, 2004

5 Yamamoto S, Suzuki H, Ueda N, Takahashi Y, Yoshimoto T, Mammalian lipoxygenases. The Eicosanoids (Curtis-Prior P, ed) John Wiley & Sons, London, pp. 53-59, 2004

２００３

1 Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama R, Ueda N, Gonzalez FJ, Takahama Y, Defective brain development in mice lacking the Hif-1α gene in neural cells. Mol Cell Biol 23:6739-6749, 2003

2 Vandevoorde S, Tsuboi K, Ueda N, Jonsson KO, Fowler CJ, Lambert DM, Esters, retroesters and retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoylethanolamine-selective acid amidase. J Med Chem 46:4373-4376, 2003

3 坪井一人，上田夏生，COXとプロスタグランジン. Hormone Frontier in Gynecology 10:265-270, 2003

4 坪井一人，上田夏生，新規エイコサノイド受容体の発見. ビタミン 77:32-35, 2003

２００２

1 Liu Q, Tonai T, Ueda N, Activation of N-acylethanolamine-releasing phospholipase D by polyamines. Chem Phys Lipids 115:77-84, 2002

2 Deutsch DG, Ueda N, Yamamoto S, The fatty acid amide hydrolase (FAAH). Prostag Leukotr Essent Fatty Acids 66:201-210, 2002

3 Ueda N, Endocannabinoid hydrolases. Prostag Oth Lipid Mediators 68-69:521-534, 2002

4 上田夏生，内在性抗炎症脂質 N-アシルエタノールアミンの合成酵素と分解酵素. 日本応用酵素協会誌，37:9-18, 2002

5 上田夏生, LXの種類と作用について解説してください.  これだけは知っておきたいアラキドン酸カスケードQ&A (室田誠逸編) 医薬ジャーナル社, 大阪, 24-26, 2002

6 上田夏生, 新しいアラキドン酸カスケードの一員に加わったアナンダミドについて解説してください. またアナンダミドが内因性のマリファナ様物質であるということはどういうことですか. これだけは知っておきたいアラキドン酸カスケードQ&A (室田誠逸編) 医薬ジャーナル社, 大阪, 43-45, 2002

２００１

1 Ding J, Ichikawa M, Furukawa A, Tomita S, Tanaka K, Ichikawa Y, Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts. Int J Biochem Cell Biol 33:603-612, 2001

2 Jiang H-B, Ichikawa M, Furukawa A, Tomita S, Ohnishi T, Ichikawa Y, Metabolic activation of mitomycin C by NADPH-ferredoxin reductase in vitro. Life Sci 68:1677-1685, 2001

3 Ueda N, Yamanaka K, Yamamoto S, Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance. J Biol Chem 276:35552-35557, 2001

4 Jiang H-B, Yoneyama H, Furukawa A, Hamamoto T, Takahara J, Ichikawa Y, Effect of isosorbide dinitrate on nitric oxide synthase under hypoxia. Pharmacology 62:10-16, 2001

5 Jiang H-B, Ichikawa M, Furukawa A, Tomita S, Ohnishi T, Ichikawa Y, The optical interconversion of the P-450 and P-420 forms of neuronal nitric oxide synthase: effects of sodium cholate, mercury chloride and urea. Int J Biochem Cell Biol 33:155-162, 2001

6 山本尚三, 鈴木秀和, 上田夏生, 内因性カンナビノイド様アラキドン酸代謝物. 化学と生物, 39:293-300, 2001

7 上田夏生, アナンダミド加水分解酵素. プロスタグランジン研究の新展開 (室田誠逸, 山本尚三編) 東京化学同人, 東京, 162-165, 2001

２０００

1 Jiang H-B, Ichikawa M, Furukawa A, Tomita S, Ichikawa Y, Reductive activation of mitomycin C by neuronal nitric oxide synthase. Biochem Pharmacol 60:571-579, 2000

１９９９

1 Jiang H-B, Ichikawa Y, Neuronal nitric oxide synthase catalyzes the reduction of 7-ethoxyresorufin. Life Sci 65:1257-1264, 1999

2 Yoneyama H, Kosaka H, Ohnishi T, Kawazoe T, Mizoguchi K, Ichikawa Y, Reaction of neuronal nitric oxide synthase with the nitric oxide spin-trapping agent, iron complexed with N-dithiocarboxysarcosine. Eur J Biochem 266:771-777, 1999

3 Huang D-Y, Furukawa A, Ichikawa Y, Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. Arch Biochem Biophys 364:264-272, 1999

4 Huang D-Y, Ohnishi T, Jiang H, Furukawa A, Ichikawa Y, Inhibition by retinoids benzo(a)pyrene metabolism catalyzed by 3-methylcholanthrene-induced rat cytochrome P-450 1A1. Metabolism 48:689-692, 1999

5 Iwahashi K, Yoshihara E, Nakamura K, Ameno K, Watanabe M, Tsuneoka Y, Ichikawa Y, Igarashi K, CYP2D6 HhaI genotype and the neuroleptic malignant syndrome. Neuropsychobiology 39:33-37, 1999

１９９８

1 Tsuneoka Y, Matsuo Y, Ichikawa Y, Watanabe Y, Genetic analysis of the CYP2D6 gene in patients with Parkinson's disease. Metabolism 47:94-96, 1998

2 Okuyama E, Yamamoto R, Ichikawa Y, Tsubaki M, Structural basis for the electron transfer across the chromaffin vesicle membranes catalyzed by cytochrome b561: analyses of cDNA nucleotide sequences and visible absorption spectra. Biochim Biophys Acta-Protein Struct Mol Enzym 1383:269-278, 1998

3 Tsubaki M, Matsumoto N, Tomita S, Ichikawa Y, Hori H, 20β-hydroxy-C21-steroid 20β-oxidase activity of cytochrome P450c21 purified from bovine adrenocortical microsomes. Biochim Biophys Acta-Mol Cell Biol Lipids 1390:197-206, 1998

4 Furukawa A, Miyatake A, Ohnishi T, Ichikawa Y, Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous ststem: colocalization of StAR, cytochrome P-450scc(CYP XIA1) , and 3β-hydroxysteroid dehydrogenase in the rat brain. J Neurochem 71:2231-2238, 1998

１９９７

1 Ohnishi T, Ichikawa Y, Direct inhibitions of the activities of steroidogenic cytochrome P-450 mono-oxygenase systems by anticonvulsants. J Steroid Biochem Molec Biol 60:77-85, 1997

2 Furukawa A, Okuyama E, Sumi T, Ichikawa Y, Molecular cloning of sheep and goat ferredoxin reductase messenger ribonucleic acids, and identification of an alternatively spliced from of sheep ferredoxin reductase. Biol Reprod 56:1336-1342, 1997

3 Iwahashi K,　Nakamura K, Furukawa A, Okuyama E, Miyatake R, Ichikawa Y, Suwaki H, No linkage of the cytochrome P-450IIE1 (CYP2E1) C1/C2 polymorphism to schizophrenia. Hum Exp Toxicol 16:208-211, 1997

4 Yoneyama H, Hori H, Ichikawa Y, Optical and electron paramagnetic resonance absorption spectra of complexes of nitric oxide synthase I with isocyanides. Biochem Biophys Acta-Gen Subjects 1335:253-264, 1997

5 Okuyama E, Nishi N, Ohnishi S, Itoh S, Ishii Y, Miyanaka H, Fujita K, Ichikawa Y, A novel splicing junction mutation in the gene for the steroidogenic acute regulatory protein causes congenital lipoid adrenal hyperplasia. J Clin Endocr Metab 82:2337-2342, 1997

6 Izuishi K, Wakabayashi H, Ohnishi T, Maeta H, Maeba T, Ichikawa Y, Effects of an immunosuppressive agent, tacrolimus (FK-506), on the activities of cytochrome P-450-linked monooxygenase systems in rat liver microsomes. Int J Biochem Cell Biol 29:921-928, 1997

7 Tsubaki M, Nakayama M, Okuyama E, Ichikawa Y, Hori H, Existence of two heme B centers in cytochrome b561 from bovine adrenal chromaffin vesicles as revealed by a new purification procedure and EPR spectroscopy. J Biol Chem 272:23206-23210, 1997

8 Huang D-Y, Ichikawa Y, Purification and characterization of a novel cytosolic NADP(H)-dependent retinol oxidoreductase from rabbit liver. Biochim Biophys Acta-Prostein Struct Mol Enzym 1338:47-59, 1997

9 Tsujita M, Wu R-F, Tomita S, Ichikawa Y, An essential amino acid sequence of the substrate (amine)-binding region of porcine FAD-containing monooxygenase. Flavins and Flavoproteins 1996 (Yagi K, ed) University of Calgary Press, pp. 391-394, 1997

10 市川佳幸, アルコールの代謝概論. 日本臨床, 55:22-27, 1997

11 市川佳幸, ミクロソームのエタノール酸化酵素系（シトクロムP-450）. 日本臨床, 55:40-45, 1997