研究論文

• Uyama T, Sasaki S, Okada-Iwabu M, Murakami M. Recent Progress in N-Acylethanolamine Research: Biological Functions and Metabolism Regulated by Two Distinct N-Acyltransferases: cPLA2ε and PLAAT Enzymes. Int J Mol Sci. 26, 3359, 2025
• Uyama T, Sasaki S, Sikder MM, Okada-Iwabu M, Ueda N. The PLAAT family as phospholipid-related enzymes. Prog Lipid Res. 98, 101331, 2025
• Okazaki-Hada M, Nagao M, Asai A, Okada-Iwabu M, Hizuka N, Eliasson L, Sugihara H, Fukuda I, Iwabu M. Potential Utility of Circulating MicroRNA-483 as a Biomarker for IGF-II-Associated Non-Islet Cell Tumor Hypoglycemia. J Clin Endocrinol Metab. gae879, 2024
• Sikder MM, Sasaki S, Miki Y, Nagasaki Y, Ohta KI, Hussain Z, Saiga H, Ohmura-Hoshino M, Hoshino K, Ueno M, Okada-Iwabu M, Murakami M, Ueda N, Uyama T. PLAAT5 as an N-acyltransferase responsible for the generation of anti-inflammatory N-acylethanolamines in testis. Biochim Biophys Acta Mol Cell Biol Lipids. 1870, 159583, 2024
• Kobori T, Iwabu M, Okada-Iwabu M, Ohuchi N, Kikuchi A, Yamauchi N, Kadowaki T, Yamauchi T, Kasuga M. Decreased AdipoR1 signaling and its implications for obesity-induced male infertility. Sci Rep. 14, 5701, 2024
• Asahara N, Okada-Iwabu M, Iwabu M, Wada K, Oka K, Yamauchi T, Kadowaki T. A monoclonal antibody activating AdipoR for type 2 diabetes and nonalcoholic steatohepatitis. Sci Adv. 9, eadg4216, 2023.
• Iwabu M, Okada-Iwabu M, Kadowaki T, Yamauchi T. Elucidating exercise-induced skeletal muscle signaling pathways and applying relevant findings to preemptive therapy for lifestyle-related diseases. Endocr J. 69, 1-8, 2022
• Ohn J, Been KW, Kim JY, Kim EJ, Park T, Yoon HJ, Ji JS, Okada-Iwabu M, Iwabu M, Yamauchi T, Kim YK, Seok C, Kwon O, Kim KH, Lee HH, Chung JH. Discovery of a transdermally deliverable pentapeptide for activating AdipoR1 to promote hair growth. EMBO Mol Med. 13, e13790, 2021
• Iwabu M#, Okada-Iwabu M#*, Tanabe H, Ohuchi N, Miyata K, Kobori T, Odawara S, Kadowaki Y, Yokoyama S, Yamauchi T*, Kadowaki T*. AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice. Commun Biol. 4, 45, 2021 (#These authors contributed equally to this work., *corresponding author)
• Mizuno-Iijima S, Ayabe S, Kato K, Matoba S, Ikeda Y, Dinh TTH, Le HT, Suzuki H, Nakashima K, Hasegawa Y, Hamada Y, Tanimoto Y, Daitoku Y, Iki N, Ishida M, Ibrahim EAE, Nakashiba T, Hamada M, Murata K, Miwa Y, Okada-Iwabu M, Iwabu M, Yagami KI, Ogura A, Obata Y, Takahashi S, Mizuno S, Yoshiki A, Sugiyama F. Efficient production of large deletion and gene fragment knock-in mice mediated by genome editing with Cas9-mouse Cdt1 in mouse zygotes. Methods. 191, 23-31, 2021
• Tanabe H#, Fujii Y#, Okada-Iwabu M#, Iwabu M#, Kano K, Kawana H, Hato M, Nakamura Y, Terada T, Kimura-Someya T, Shirouzu M, Kawano Y, Yamamoto M, Aoki J, Yamauchi T, Kadowaki T, Yokoyama S. Human adiponectin receptor AdipoR1 assumes closed and open structures. Commun Biol. 3, 446, 2020 (#These authors contributed equally to this work.)
• Futatsugi H, Iwabu M, Okada-Iwabu M, Okamoto K, Amano Y, Morizaki Y, Kadowaki T, Yamauchi T. Blood Glucose Control Strategy for Type 2 Diabetes Patients With COVID-19. Front Cardiovasc Med. 7, 593061, 2020
• Okada-Iwabu M*, Iwabu M, Yamauchi T, Kadowaki T. Drug development research for novel adiponectin receptor-targeted antidiabetic drugs contributing to healthy longevity. Diabetology Int. 10, 237-244, 2019 (*Corresponding Author)
• Iwabu M, Okada-Iwabu M, Yamauchi T, Kadowaki T. Adiponectin/AdipoR Research and Its Implications for Lifestyle-Related Diseases. Front Cardiovasc Med. 6, 116, 2019
• Okada-Iwabu M*, Iwabu M, Yamauchi T, Kadowaki T. Structure and function analysis of adiponectin receptors toward development of novel antidiabetic agents promoting healthy longevity. Endocr J. 65, 871-977, 2018 (*Corresponding Author)
• Iwabu M, Okada-Iwabu M, Yamauchi T, Kadowaki T. Effects of aerobic exercise on adiponectin and glucose metabolism. Diabetes Frontier Online 5, 37-43, 2018
• Odawara S, Nemoto K, Nakagawa T, Takahashi O, Kobayashi D, Iwabu M, Okada-Iwabu M, Yamauchi T, Kadowaki T, Izumo H. Usefulness of post-delivery oral glucose tolerance test in women with gestational diabetes mellitus. Diabetes Frontier Online 5, 44-49, 2018
• Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Nakamura Y, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, Ogasawara S, Hino T, Murata T, Iwata S, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S. Crystal structures of the human adiponectin receptors. Nature 520, 312-316, 2015
• Shiomi Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Nakayama R, Orikawa Y, Yoshioka Y, Tanaka K, Ueki K, Kadowaki T. A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice. J. Biol. Chem. 290, 14567-14581, 2015
• Tanabe H, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hosaka T, Hato M, Fujii Y, Nakamura Y, Ogasawara S, Hino T, Murata T, Iwata S, Okada-Iwabu M, Iwabu M, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S. Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2. J Struct Funct Genomics. 16, 11-23, 2015
• Iwabu M, Okada-Iwabu M, Yamauchi T, Kadowaki T. Adiponectin/adiponectin receptor in disease and aging. NPJ Aging Mech. Dis. 1, 15013, 2015
• Okada-Iwabu M, Iwabu M, Ueki K, Yamauchi T, Kadowaki T. Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity. Diabetes Metab. J. 39, 363-372, 2015
• Yamauchi T, Iwabu M, Okada-Iwabu M, Kadowaki T. Adiponectin receptors: A review of their structure, function and how they work. Best Pract Res Clin Endocrinol Metab. 1, 15-23, 2014
• Kadowaki T, Yamauchi T, Okada-Iwabu M, Iwabu M. Adiponectin and its receptors: implications for obesity-associated diseases and longevity. Lancet Diabetes Endocrinol. 2, 8-9, 2014
• Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503, 493-498, 2013
• Nio Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Funata M, Yamaguchi M, Ueki K, Kadowaki T. Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice. Diabetologia 255, 3350-3358, 2012
• Yamauchi N, Takazawa Y, Maeda D, Hibiya T, Tanaka M, Iwabu M, Okada-Iwabu M, Yamauchi T, Kadowaki T, Fukayama M. Expression Levels of Adiponectin Receptors are Decreased in Human Endometrial Adenocarcinoma Tissues. Int J Gynecol Pathol. 31, 352-357, 2012
• Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Ohshige T, Omori S, Iwata M, Hirose H, Kaku K, Ito C, Tanaka Y, Tobe K, Kashiwagi A, Kawamori R, Kasuga M, Kamatani N; Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Nakamura Y, Kadowaki T. A single nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum Mol Genet. 21, 3042-3049, 2012
• Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J, Aburatani H, Kadowaki T. Global Mapping of Cell Type-Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation. PLoS Genet. 7, e1002311, 2011
• Kukimoto-Niino M, Yoshikawa S, Takagi T, Ohsawa N, Tomabechi Y, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S. Crystal structure of the CA2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J. Biol. Chem. 286, 22570-22579, 2011
• Handa N, Takagi T, Saijo S, Kishishita S, Takaya D, Toyama M, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyama S. Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain. Acta. Crystallogr. D BiolCrystallogr. 67, 480-487, 2011
• Kadowaki T, Yamauchi T, Waki H, Iwabu M, Okada-Iwabu M, Nakamura M. Adiponectin, adiponectin receptors, and epigenetic regulation of adipogenesis. Cold Spring Harb Symp Quant Biol. 76, 257-265, 2011
• Yamauchi T, Hara K, Maeda S, Yasuda K, Takahashi A, Horikoshi M, Nakamura M, Fujita H, Grarup N, Cauchi S, Ng DP, Ma RC, Tsunoda T, Kubo M, Watada H, Maegawa H, Okada-Iwabu M, Iwabu M, Shojima N, Shin HD, Andersen G, Witte DR, Jørgensen T, Lauritzen T, Sandbæk A, Hansen T, Ohshige T, Omori S, Saito I, Kaku K, Hirose H, So WY, Beury D, Chan JC, Park KS, Tai ES, Ito C, Tanaka Y, Kashiwagi A, Kawamori R, Kasuga M, Froguel P, Pedersen O, Kamatani N, Nakamura Y, Kadowaki T. A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nature Genetics 42, 864-868, 2010
• Iwabu M#, Yamauchi T#, Okada-Iwabu M#, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi K Y, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T. Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1. Nature 464, 1313-1319, 2010 (#These authors contributed equally to this work.)
• Takazawa T, Yamauchi T, Tsuchida A, Takata M, Hada Y, Iwabu M, Okada-Iwabu M, Ueki K, Kadowaki T. Peroxisome proliferator-activated receptor (gamma) agonist rosiglitazone increases the expression of very low density lipoprotein receptor gene in adipocytes. J. Biol. Chem. 284, 30049-30057, 2009
• Uchida-Kitajima S, Yamauchi T, Takashina Y, Okada-Iwabu M, Iwabu M, Ueki K, Kadowaki T. 5-Hydroxytryptamine 2A receptor signaling cascade modulates adiponectin and plasminogen activator inhibitor 1 expression in adipose tissue. FEBS Lett. 582, 3037-3044, 2008
• Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide, T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadowaki T. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature Medicine 13, 332-339, 2007
• Kubota N, Terauchi Y, Tobe K, Yano W, Suzuki R, Ueki K, Takamoto I, Satoh H, Maki T, Kubota T, Moroi M, Okada-Iwabu M, Ezaki O, Nagai R, Ueta Y, Kadowaki T, Noda T. Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J. Clin. Invest. 114, 917-927, 2004
• Hatakeyama T, Okada M, Shimamoto S, Kubota Y, Kobayashi R. Identification of intracellular target proteins of the calcium-signaling protein S100A12. Eur. J. Biochem. 271, 3765-3775, 2004
• Okada M, Hatakeyama T, Itoh H, Tokuta N, Tokumitsu H, Kobayashi R. S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complex. J. Biol. Chem. 279, 4221-4233, 2004
• Okada M, Takezawa D, Tachibanaki S, Kawamura S, Tokumitsu H, Kobayashi R. Neuronal calcium sensor proteins are direct targets of the insulinotropic agent repaglinide. Biochem. J. 375, 87-97, 2003
• Okada M, Itoh H, Hatakeyama T, Tokumitsu H, Kobayashi R. Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. Biochem. J. 374, 433-441, 2003
• Okada M, Tokumitsu H, Kubota Y, Kobayashi R. Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 protein. Biochem. Biophys. Res. Commun. 292, 1023-1030, 2002
• Furuichi, H., Yamashita K, Okada M, Toyoshima T, Hata Y, Suzuki S, Itano T, Shishibori T, Tokumitsu H, Kobayashi R. Identification of tranilast-binding protein as 36-kDa microfibril-associated glycoprotein by drug affinity chromatography, and its localization in human skin. Biochem. Biophys. Res. Commun. 270, 1002-1008, 2000

生化学教室研究論文アーカイブ

• Sikder MM, Uyama T, Sasaki S, Kawai K, Araki N, Ueda N, PLAAT1 expression triggers fragmentation of mitochondria in an enzyme activity-dependent manner. J Biochem. 175:101-113, 2024
• Ayaki S, Mii T, Matsuno K, Tokuyama T, Tokuyama T, Tokuyama T, Uyama T, Ueda N, β-1,4-Galactan suppresses lipid synthesis in sebaceous gland cells via TLR4. J Biochem 173:85-94, 2023
• Kittikulsuth W, Nakano D, Kitada K, Uyama T, Ueda N, Asano E, Okano K, Matsuda Y, Nishiyama A. Vasoactive intestinal peptide blockade suppresses tumor growth by regulating macrophage polarization and function in CT26 tumor-bearing mice. Sci Rep 13:927, 2023
• Uyama T, Ueda N, Assay of NAT activity. Methods Mol Biol 2576:213-224, 2023
• Tsuboi K, Ueda N, Assay of NAAA activity. Methods Mol Biol 2576:261-274, 2023
• Tevosian M, Todorov H, Lomazzo E, Bindila L, Ueda N, Bassetti D, Warm D, Kirischuk S, Luhmann HJ, Gerber S, Lutz B, NAPE-PLD deletion in stress-TRAPed neurons results in an anxiogenic phenotype. Transl Psychiatry 13:152, 2023
• Maccarrone M, Di Marzo V, Gertsch J, Grether U, Howlett AC, Hua T, Makriyannis A, Piomelli D, Ueda N, van der Stelt M, Goods and bads of endocannabinoid system as a therapeutic target: Lessons learned after 30 years. Pharmacol Rev 2023 May 10. doi: 10.1124/pharmrev.122.000600.
• GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator. Kitakaze K, Ali H, Kimoto R, Takenouchi Y, Ishimaru H, Yamashita A, Ueda N, Tanaka T, Okamoto Y, Tsuboi K, Commun Biol 6(1):524, 2023
• Rahman SMK, Sasaki S, Uyama T, Hussain Z, Sikder MM, Saiga H, Ohmura-Hoshino M, Ohta KI, Miki Y, Hoshino K, Ueno M, Murakami M, Ueda N, PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid accumulation in mice. FASEB J. 37:e23032, 2023
• Rahman SMK, Hussain Z, Morito K, Takahashi N, Sikder MM, Tanaka T, Ohta K, Ueno M, Takahashi H, Yamamoto T, Murakami M, Uyama T, Ueda N, Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε in an ex vivo murine model of brain ischemia. Biochim Biophys Acta - Mol Cell Biol Lipids 1867:159222,2022
• Watanabe S, Nihongaki Y, Itoh K, Uyama T, Toda S, Watanabe S, Inoue T, Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases. Nat Commun 13:4413, 2022
• Guo Y, Uyama T, Rahman K, Sikder MM, Hussain Z, Tsuboi K, Miyake M, Ueda N, Involvement of γ isoform of cPLA2in the biosynthesis of bioactive N-acylethanolamines. Molecules 26 (17): 5213, 2021
• Rahman SMK, Uyama T, Hussain Z, Ueda N, Roles of endocannabinoids and endocannabinoid-like molecules in energy homeostasis and metabolic regulation: a nutritional perspective. Annu Rev Nutr 41:177-202, 2021
• Tsuboi K, Tai T, Yamashita R, Ali H, Watanabe T, Uyama T, Okamoto Y, Kitakaze K, Takenouchi Y, Go S, Rahman IAS, Houchi H, Tanaka T, Okamoto Y, Tokumura A, Matsuda J, Ueda N, Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines. Biochim Biophys Acta - Mol Cell Biol Lipids 1866, 158972. doi: 10.1016/j.bbalip.2021.158972. Epub 2021 May 24.
• Tsuboi K, Uyama T, Ueda N, Chapter 7 Inhibition of NAPE-PLD Activity by Natural Compounds and Synthetic Drugs, and Its Biological Relevance. New Tools to Interrogate Endocannabinoid Signalling: From Natural Compounds to Synthetic Drugs (Ed., Mauro Maccarrone), RSC Drug Discovery Series 2021-January (76), pp. 301-336
• Yamamoto K, Ueda N, In Memoriam: Shozo Yamamoto (1933-2020). J Lipid Res 61:1305-1306, 2020
• Binte Mustafiz SS, Uyama T, Morito K, Takahashi N, Kawai K, Hussain Z, Tsuboi K, Araki N, Yamamoto K, Tanaka T, Ueda N, Intracellular Ca2+-dependent formation of N-acyl-phosphatidylethanolamines by human cytosolic phospholipase A2ε. Biochim Biophys Acta-Mol Cell Biol Lipids 1864, doi: 10.1016/j.bbalip.2019.158515
• Mustafiz SSB, Uyama T, Hussain Z, Kawai K, Tsuboi K, Araki N, Ueda N, The role of intracellular anionic phospholipids in the production of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ɛ. J Biochem 165:343-352, 2019
• Tsuboi K, Uyama T, Okamoto Y, Ueda N, Endocannabinoids and related N-acylethanolamines: biological activities and metabolism. Inflamm Regen 38:28, 2018
• Hussain Z, Uyama T, Kawai K, Mustafiz SSB, Tsuboi K, Araki N, Ueda N, Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca2+-dependent N-acyltransferase. Biochim Biophys Acta-Mol Cell Biol Lipids 1863:493-502, 2018
• Binte Mustafiz SS, Uyama T, Hussain Z, Tsuboi K, Ueda N, The biosynthetic pathways of N-acylethanolamines in mammals. eLS, John Wiley & Sons, Ltd, 2018. DOI: 10.1002/9780470015902.a0027711
• Hussain Z, Uyama T, Tsuboi K, Ueda N, Mammalian enzymes responsible for the biosynthesis of N-acylethanolamines. Biochim Biophys Acta-Mol Cell Biol Lipids 1862:1546-1561, 2017
• Uyama T, Tsuboi K, Ueda N, An involvement of phospholipase A/acyltransferase family proteins in peroxisome regulation and plasmalogen metabolism. FEBS Lett 591:2745-2760, 2017
• Inoue M, Tsuboi K, Okamoto Y, Hidaka M, Uyama T, Tsutsumi T, Tanaka T, Ueda N, Tokumura A, Peripheral tissue levels and molecular species compositions of N-acyl-phosphatidylethanolamine and its metabolites in mice lacking N-acyl-phosphatidylethanolamine-specific phospholipase D. J Biochem 162:449-458, 2017
• Sousa-Valente J, Varga A, Torres Perez JV, Jenes A, Wahba J, Mackie K, Cravatt B, Ueda N, Tsuboi K, Santha P, Jancso G, Tailor H, Avelino A, Nagy I, Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium-sensitive N-arachydonoylethanolamine-synthesizing enzyme and related molecules in rat primary sensory neurons. J Comp Neurol 525:1778-1796, 2017
• Hussain Z, Uyama T, Kawai K, Rahman IA, Tsuboi K, Araki N, Ueda N, Comparative analyses of isoforms of the calcium-independent phosphatidylethanolamine N-acyltransferase PLAAT-1 in humans and mice. J Lipid Res 57:2051-2060, 2016
• Sakura Y, Tsuboi K, Uyama T, Zhang X, Taoka R, Sugimoto M, Kakehi Y, Ueda N A quantitative study on splice variants of N-acylethanolamine acid amidase in human prostate cancer cells and other cells. Biochim Biophys Acta-Mol Cell Biol Lipids 1861:1951-1958, 2016
• Rahman IAS, Tsuboi K, Hussain Z, Yamashita R, Okamoto Y, Uyama T, Yamazaki N, Tanaka T, Tokumura A, Ueda N, Calcium-dependent generation of N-acylethanolamines and lysophosphatidic acids by glycerophosphodiesterase GDE7. Biochim Biophys Acta-Mol Cell Biol Lipids 1861:1881-1892, 2016
• Uyama T, Ueda N, Assay of NAT activity. Methods Mol Biol 1412, Endocannabinoid Signaling: Methods and Protocols (Maccarrone M, ed) Humana Press, 112-122, 2016 (ISBN: 978-1-4939-3537-6)
• Tsuboi K, Ueda N, Assay of NAAA activity. Methods Mol Biol 1412, Endocannabinoid Signaling: Methods and Protocols (Maccarrone M, ed) Humana Press, 137-148, 2016 (ISBN: 978-1-4939-3537-6)
• Uyama T, Kawai K, Kono N, Watanabe M, Tsuboi K, Inoue T, Araki N, Arai H, Ueda N, Interaction of phospholipase A/acyltransferase-3 with Pex19p: a possible involvement in the downregulation of peroxisomes. J Biol Chem 290:17520-17534, 2015
• Tsuboi K, Okamoto Y, Rahman IAS, Uyama T, Inoue T, Tokumura A, Ueda N, Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a possible involvement in bioactive N-acylethanolamine biosynthesis. Biochim Biophys Acta - Mol Cell Biol Lipids 1851:537-548, 2015
• Rahman IAS, Tsuboi K, Uyama T, Ueda N, New players in the fatty acyl ethanolamide metabolism. Pharmacol Res 86:1-10, 2014
• Ueda N, Tsuboi K, Uyama T, CHAPTER 8 Metabolic Enzymes for Endocannabinoids and Endocannabinoid-Like Mediators. The Endocannabinoidome: The World of Endocannabinoids and Related Mediators (Di Marzo V, Wang J, eds) Elsevier, pp. 111-135, 2015 (ISBN: 978-0-12-420126-2)
• Uyama T, Inoue M, Okamoto Y, Shinohara N, Tai T, Tsuboi K, Inoue T, Tokumura A, Ueda N, Involvement of phospholipase A/acyltransferase-1 in N-acylphosphatidylethanolamine generation. Biochim Biophys Acta - Mol Cell Biol Lipids 1831:1690-1701, 2013
• Ueda N, Tsuboi K, Uyama T, Metabolism of endocannabinoids and related N-acylethanolamines: Canonical and alternative pathways, FEBS J 280:1874-1894, 2013
• Tsuboi K, Ikematsu N, Uyama T, Deutsch D.G, Tokumura A, Ueda N, Biosynthetic pathways of bioactive N-acylethanolamines in brain. CNS Neurol Disord - Drug Targets 12:7-16, 2013
• Uyama T, Ikematsu N, Inoue M, Shinohara N, Jin X-H, Tsuboi K, Tonai T, Tokumura A, Ueda N, Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. J Biol Chem 287:31905-31919, 2012
• Ueda N, Tsuboi K, Preview: discrimination between two endocannabinoids. Chem Biol 19:545-547, 2012
• Yamano Y, Tsuboi K, Hozaki Y, Takahashi K, Jin X-H, Ueda N, Wada A, Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase. Bioorg Med Chem 20:3658-3665, 2012
• Kallendrusch S, Hobusch C, Ehrlich A, Ziebell S, Ueda N, Geisslinger G, Koch M, Dehghani F, Site-specific and time-dependent activation of the endocannabinoid system after transection of long-range projections. PLoS ONE 7:e33537, 2012
• Tai T, Tsuboi K, Uyama T, Masuda K, Cravatt BF, Houchi H, Ueda N, Endogenous molecules stimulating N-acylethanolamine-hydrolyzing acid amidase (NAAA). ACS Chem Neurosci 3:379-385, 2012
• Uyama T, Ichi I, Kono N, Inoue A, Tsuboi K, Jin X-H, Araki N, Aoki J, Arai H, Ueda N, Regulation of peroxisomal lipid metabolism by catalytic activity of tumor suppressor H-rev107. J Biol Chem 287:2706-2718, 2012
• Shinohara N, Uyama T, Jin X-H, Tsuboi K, Tonai T, Houchi H, Ueda N, Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes. J Lipid Res 52:1927-1935, 2011
• Tsuboi K, Okamoto Y, Ikematsu N, Inoue M, Shimizu Y, Uyama T, Wang J, Deutsch DG, Burns MP, Ulloa NM, Tokumura A, Ueda N, Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. Biochim Biophys Acta - Mol Cell Biol Lipids 1811:565-577, 2011
• Wellner N, Tsuboi K, Madsen AN, Holst B, Diep TA, Nakao M, Tokumura A, Burns MP, Deutsch DG, Ueda N, Hansen HS, Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice. Biochim Biophys Acta - Mol Cell Biol Lipids 1811:508-512, 2011
• Ueda N, Tsuboi K, Uyama T, Ohnishi T, Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol. BioFactors 37:1-7, 2011
• Ueda N, Tsuboi K, Uyama T, Enzymological studies on the biosynthesis of N-acylethanolamines. Biochim Biophys Acta - Mol Cell Biol Lipids 1801:1274-1285, 2010
• Ueda N, Tsuboi K, Uyama T, N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA). Prog Lipid Res 49:299-315, 2010
• Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D'Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V, Protective role of palmitoylethanolamide in contact allergic dermatitis. Allergy 65:698-711, 2010
• Jin X-H, Uyama T, Wang J, Okamoto Y, Tonai T, Ueda N, cDNA cloning and characterization of human and mouse Ca2+-independent phosphatidylethanolamine N-acyltransferases. Biochim Biophys Acta - Mol Cell Biol Lipids 1791:32-38, 2009
• Shiratsuchi A, Ichiki M, Okamoto Y, Ueda N, Sugimoto N, Takuwa Y, Nakanishi Y, Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc42. J Biochem 145:43-50, 2009
• Uyama T, Morishita J, Jin X-H, Okamoto Y, Tsuboi K, Ueda N, The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase-type. J Lipid Res 50:685-693, 2009
• Uyama T, Jin X-H, Tsuboi K, Tonai T, Ueda N, Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. Biochim Biophys Acta - Mol Cell Biol Lipids 1791:1114-1124, 2009
• Wang J, Ueda N, Biology of endocannabinoid synthesis system. Prostaglandins Other Lipid Mediat 89:112-119, 2009
• Okamoto Y, Tsuboi K, Ueda N, Enzymatic formation of anandamide. Vitam Horm 81:1-24, 2009
• Wang J, Zhao L-Y, Uyama T, Tsuboi K, Wu X-X, Kakehi Y, Ueda N, Expression and secretion of N-acylethanolamine-hydrolyzing acid amidase in human prostate cancer cells. J Biochem 144:685-690, 2008
• Wang J, Zhao L-Y, Uyama T, Tsuboi K, Tonai T, Ueda N, Amino acid residues crucial in pH regulation and proteolytic activation of N-acylethanolamine-hydrolyzing acid amidase. Biochim Biophys Acta - Mol Cell Biol Lipids 1781:710-717, 2008
• Placzek EA, Okamoto Y, Ueda N, Barker EL, Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown. Neuropharmacology 55:1095-1104, 2008
• Placzek EA, Okamoto Y, Ueda N, Barker EL, Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. J Neurochem 107:987-1000, 2008
• Iwanaga Y, Ueno M, Ueki M, Huang C-L, Tomita S, Okamoto Y, Ogawa T, Ueda N, Maekawa N, Sakamoto H, The expression of osteopontin is increased in vessels with blood-brain barrier impairment. Neuropath Appl Neurobiol 34:145-154, 2008
• Cristino L, Starowicz K, De Petrocellis L, Morishita J, Ueda N, Guglielmotti V, Di Marzo V, Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain. Neuroscience 151:955-968, 2008
• Wang J, Arts and Science Faculty of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD). Neuropharmacology 54:8-15, 2008
• Wang J, Ueda N, Role of the endocannabinoid system in metabolic control. Curr Opin Nephrol Hypertens 17:1-10, 2008
• Okamoto Y, Wang J, Morishita J, Ueda N, Biosynthetic pathways of the endocannabinoid anandamide. Chem Biodivers 4:1842-1857, 2007
• Jin X-H, Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N, Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. J Biol Chem 282:3614-3623, 2007
• Tsuboi K, Zhao L-Y, Okamoto Y, Araki N, Ueno M, Sakamoto H, Ueda N, Predominant expression of N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies. Biochim Biophys Acta - Mol Cell Biol Lipids, 1771:623-632, 2007
• Zhao L-Y, Tsuboi K, Okamoto Y, Nagahata S, Ueda N, Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism. Biochim Biophys Acta - Mol Cell Biol Lipids, 1771:1397-1405, 2007
• Tsuboi K, Molecular characterization of a novel lysosomal enzyme degrading the anti-inflammatory lipid mediator N-acylethanolamine. Inflammation and Regeneration 27:18-27, 2007
• Tsuboi K, Takezaki N, Ueda N, The N-acylethanolamine-hydrolyzing acid amidase (NAAA). Chem Biodivers 4:1914-1925, 2007
• Ding J, Tsuboi K, Hoshikawa H, Goto R, Mori N, Katsukawa M, Hiraki E, Yamamoto S, Abe M, Ueda N, Cyclooxygenase isozymes are expressed in human myeloma cells but not involved in anti-proliferative effect of cyclooxygenase inhibitors. Mol Carcinog 45:250-259, 2006
• Wang J, Okamoto Y, Morishita J, Tsuboi K, Miyatake A, Ueda N, Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-β-lactamase family. J Biol Chem 281:12325-12335, 2006
• Tsuboi K, Sun Y-X, Okamoto Y, Araki N, Tonai T, Ueda N, Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. J Biol Chem 280:11082-11092, 2005
• Okamoto Y, Morishita J, Wang J, Schmid PC, Krebsbach RJ, Schmid HHO, Ueda N, Mammalian cells stably overexpressing N-acylphosphatidylethanolamine-hydrolyzing phospholipase D exhibit significantly decreased levels of N-acylphosphatidylethanolamines. Biochem J 389:241-247, 2005
• Morishita J, Okamoto Y, Tsuboi K, Ueno M, Sakamoto H, Maekawa N, Ueda N, Regional distribution and age-dependent expression of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D in rat brain. J Neurochem 94:753-762, 2005
• Guo Y, Wang H, Okamoto Y, Ueda N, Kingsley PJ, Marnett LJ, Schmid HHO, Das SK, Dey SK, N-Acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. J Biol Chem 280:23429-23432, 2005
• Sun Y-X, Tsuboi K, Zhao L-Y, Okamoto Y, Lambert DM, Ueda N, Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages. Biochim Biophys Acta 1736:211-220, 2005
• Yamamoto S, Katsukawa M, Nakano A, Hiraki E, Nishimura K, Jisaka M, Yokota K, Ueda N, Arachidonate 12-lipoxygenases with reference to their selective inhibitors. Biochem Biophys Res Commun 338:122-127, 2005
• Ueda N, Tsuboi K, Lambert DM, A second N-acylethanolamine hydrolase in mammalian tissues. Neuropharmacology 48:1079-1085, 2005
• Ueda N, Okamoto Y, Tsuboi K, Endocannabinoid-related enzymes as drug targets with special reference to N-acylphosphatidylethanolamine-hydrolyzing phospholipase D. Curr Med Chem 12:1413-1422, 2005
• Ueda N, Okamoto Y, Morishita J, N-Acylphosphatidylethanolamine-hydrolyzing phospholipase D: a novel enzyme of the β-lactamase fold family releasing anandamide and other N-acylethanolamines. Life Sci 77:1750-1758, 2005
• Tsuboi K, Hilligsmann C, Vandevoorde S, Lambert DM, Ueda N, N-Cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase. Biochem J 379:99-106, 2004
• Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N, Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem 279:5298-5305, 2004
• Sun Y-X, Tsuboi K, Okamoto Y, Tonai T, Murakami M, Kudo I, Ueda N, Biosynthesis of anandamide and N-palmitoylethanolamine by sequential actions of phospholipase A2 and lysophospholipase D. Biochem J 380:749-756, 2004
• Ueda N, Deutsch DG, Biosynthesis and degradation of anandamide, an endogenous ligand of cannabinoid receptors. The Eicosanoids (Curtis-Prior P, ed) John Wiley & Sons, London, pp. 179-187, 2004
• Yamamoto S, Suzuki H, Ueda N, Takahashi Y, Yoshimoto T, Mammalian lipoxygenases. The Eicosanoids (Curtis-Prior P, ed) John Wiley & Sons, London, pp. 53-59, 2004
• Tomita S, Ueno M, Sakamoto M, Kitahama Y, Ueki M, Maekawa N, Sakamoto H, Gassmann M, Kageyama R, Ueda N, Gonzalez FJ, Takahama Y, Defective brain development in mice lacking the Hif-1α gene in neural cells. Mol Cell Biol 23:6739-6749, 2003
• Vandevoorde S, Tsuboi K, Ueda N, Jonsson KO, Fowler CJ, Lambert DM, Esters, retroesters and retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoylethanolamine-selective acid amidase. J Med Chem 46:4373-4376, 2003
• Liu Q, Tonai T, Ueda N, Activation of N-acylethanolamine-releasing phospholipase D by polyamines. Chem Phys Lipids 115:77-84, 2002
• Deutsch DG, Ueda N, Yamamoto S, The fatty acid amide hydrolase (FAAH). Prostag Leukotr Essent Fatty Acids 66:201-210, 2002
• Ueda N, Endocannabinoid hydrolases. Prostag Oth Lipid Mediators 68-69:521-534, 2002
• Ding J, Ichikawa M, Furukawa A, Tomita S, Tanaka K, Ichikawa Y, Low synthesis of retinoic acid due to impaired cytochrome P450 1a1 expression in mouse xeroderma pigmentosum fibroblasts. Int J Biochem Cell Biol 33:603-612, 2001
• Jiang H-B, Ichikawa M, Furukawa A, Tomita S, Ohnishi T, Ichikawa Y, Metabolic activation of mitomycin C by NADPH-ferredoxin reductase in vitro. Life Sci 68:1677-1685, 2001
• Ueda N, Yamanaka K, Yamamoto S, Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance. J Biol Chem 276:35552-35557, 2001
• Jiang H-B, Yoneyama H, Furukawa A, Hamamoto T, Takahara J, Ichikawa Y, Effect of isosorbide dinitrate on nitric oxide synthase under hypoxia. Pharmacology 62:10-16, 2001
• Jiang H-B, Ichikawa M, Furukawa A, Tomita S, Ohnishi T, Ichikawa Y, The optical interconversion of the P-450 and P-420 forms of neuronal nitric oxide synthase: effects of sodium cholate, mercury chloride and urea. Int J Biochem Cell Biol 33:155-162, 2001
• Jiang H-B, Ichikawa M, Furukawa A, Tomita S, Ichikawa Y, Reductive activation of mitomycin C by neuronal nitric oxide synthase. Biochem Pharmacol 60:571-579, 2000
• Jiang H-B, Ichikawa Y, Neuronal nitric oxide synthase catalyzes the reduction of 7-ethoxyresorufin. Life Sci 65:1257-1264, 1999
• Yoneyama H, Kosaka H, Ohnishi T, Kawazoe T, Mizoguchi K, Ichikawa Y, Reaction of neuronal nitric oxide synthase with the nitric oxide spin-trapping agent, iron complexed with N-dithiocarboxysarcosine. Eur J Biochem 266:771-777, 1999
• Huang D-Y, Furukawa A, Ichikawa Y, Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. Arch Biochem Biophys 364:264-272, 1999
• Huang D-Y, Ohnishi T, Jiang H, Furukawa A, Ichikawa Y, Inhibition by retinoids benzo(a)pyrene metabolism catalyzed by 3-methylcholanthrene-induced rat cytochrome P-450 1A1. Metabolism 48:689-692, 1999
• Iwahashi K, Yoshihara E, Nakamura K, Ameno K, Watanabe M, Tsuneoka Y, Ichikawa Y, Igarashi K, CYP2D6 HhaI genotype and the neuroleptic malignant syndrome. Neuropsychobiology 39:33-37, 1999
• Tsuneoka Y, Matsuo Y, Ichikawa Y, Watanabe Y, Genetic analysis of the CYP2D6 gene in patients with Parkinson's disease. Metabolism 47:94-96, 1998
• Okuyama E, Yamamoto R, Ichikawa Y, Tsubaki M, Structural basis for the electron transfer across the chromaffin vesicle membranes catalyzed by cytochrome b561: analyses of cDNA nucleotide sequences and visible absorption spectra. Biochim Biophys Acta-Protein Struct Mol Enzym 1383:269-278, 1998
• Tsubaki M, Matsumoto N, Tomita S, Ichikawa Y, Hori H, 20β-hydroxy-C21-steroid 20β-oxidase activity of cytochrome P450c21 purified from bovine adrenocortical microsomes. Biochim Biophys Acta-Mol Cell Biol Lipids 1390:197-206, 1998
• Furukawa A, Miyatake A, Ohnishi T, Ichikawa Y, Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous ststem: colocalization of StAR, cytochrome P-450scc(CYP XIA1) , and 3β-hydroxysteroid dehydrogenase in the rat brain. J Neurochem 71:2231-2238, 1998
• Ohnishi T, Ichikawa Y, Direct inhibitions of the activities of steroidogenic cytochrome P-450 mono-oxygenase systems by anticonvulsants. J Steroid Biochem Molec Biol 60:77-85, 1997
• Furukawa A, Okuyama E, Sumi T, Ichikawa Y, Molecular cloning of sheep and goat ferredoxin reductase messenger ribonucleic acids, and identification of an alternatively spliced from of sheep ferredoxin reductase. Biol Reprod 56:1336-1342, 1997
• Iwahashi K, Nakamura K, Furukawa A, Okuyama E, Miyatake R, Ichikawa Y, Suwaki H, No linkage of the cytochrome P-450IIE1 (CYP2E1) C1/C2 polymorphism to schizophrenia. Hum Exp Toxicol 16:208-211, 1997
• Yoneyama H, Hori H, Ichikawa Y, Optical and electron paramagnetic resonance absorption spectra of complexes of nitric oxide synthase I with isocyanides.