Gastroenterology and Neurology


Prof. Masaki
  • Professor
  • Lecturer
  • Assistant Professor
  • Clinical Assistant Professor
    • Hiroki YAMANA, M.D., Ph.D.
    • Nobuya KOBAYASHI, M.D., Ph.D.
    • Takanori MATUI, M.D., Ph.D.
    • Mai NAKAHARA, M.D.
    • Naoki FUJITA, M.D., Ph.D.
    • Daisuke NAMIMA, M.D., Ph.D.
    • Toshiaki KOHNO, M.D., Ph.D.
    • Kei TAKUMA, M.D.
  • Visiting Professor
    • Masafumi ONO, M.D., Ph.D. (Liver / Biliary / Pancreatic Internal Science Advanced Medical Science Course)
    • Shima MIMURA, M.D., Ph.D.(Medicine for Community Healthcare Revitalization)
    • Shintaro FUJIHARA, M.D., Ph.D.(Community Medical Care)
  • Visiting Associate Professor
    • Kiyoyuki KOBAYASHI, M.D., Ph.D. (Liver / Biliary / Pancreatic Internal Science Advanced Medical Science Course)
  • Visiting Assistant Professor
    • Naoya TADA, M.D.(Community Medical Care)


  • Associate Professor
  • Clinical Assistant Professor
  • Visiting Professor
    • Masaki KAMADA, M.D., Ph.D.(Neurological Intractable Disease Research)
  • Visiting Associate Professor
    • Tadayuki TAKATA, M.D., Ph.D. (Department of supportive and promotive medicine of the municipal hospital)
  • Visiting Assistant Professor
    • Yasuhiro HAMADA, M.D. (Department of supportive and promotive medicine of the municipal hospital)
    • Masashi KINO, M.D.(Neurological Intractable Disease Research)

Current Research Projects

  • Analysis of the effect of the hepatic arterial infusion chemotherapy in combination with radiation for unresectable advanced hepatocellular carcinoma.
  • Analysis of liver fibrosis with elastography.
  • Analysis of the effects of partial splenic embolization (PSE) and splenectomy on decompensated cirrhosis.
  • Analysis of therapeutic effect of radiofrequency ablation for hepatocellular carcinoma using real time virtual sonography (RVS) and contrast echo.
  • Analyses of the serum micro RNAs in viral hepatitis.
Alimentary Tract
  • Animal experiments for the realization of the complete natural orifice transluminal endoscopic surgery (pure NOTES).
  • Development of endoscope-related equipment by the Medical and engineering industry-academia-government collaboration project team (Kagawa NOTES project team) - a suturing device for flexible endoscope perfectly performing the full-thickness plication of gastrointestinal tract wall, a counter traction device to expand the operative field, etc.
  • Joint development of biomedical engineering using micromachine technology (MEMS technology): Partnership with Kagawa University Faculty of Engineering microstructure device integration Research Center.
  • Endoscopic vascular transection surgery for gastroesophageal varices.
  • Relaxation incision surgery for postoperative gastrointestinal tract stenosis.
  • Preventive effect of the steroid to the gastrointestinal tract stenosis.
  • Bloc biopsy by tunneling method using endoscopic submucosal dissection for an upper gastrointestinal submucosal tumor.
  • Studies on the effectiveness of post-ESD wound surface closure and the wound closure procedures itself.
  • Basic research on the anti-tumor effect of metformin against gastrointestinal caner.
  • Basic research on the anti-tumor effect of Galectin-9 against gastrointestinal caner.
  • Micro RNA involvement in the digestive tract diseases.
Pancreas & Biliary Tract
  • Diagnosis and treatment using the endoscopic retrograde cholangiopancreatography (ERCP); EST, lithotripsy, placement of metallic stent, etc.
  • Treatment and diagnosis using the endoscopic ultrasound (EUS); EUS-FNA, EUS-PCD, EUS-BD, EUS-PD, necrosectomy on the infected pancreatic necrosis, IDUS, etc.
  • Comprehensive analysis of the micro RNA of pancreatic cancer tissue obtained by EUS-FNA.
  • Basic research on the anti-tumor effect of metformin against pancreatic cancer and biliary tract caner.
  • The development of a new tumor marker of pancreatic cancer using serum micro RNA.

Recent Publications

  • Long-Term Outcomes and Evaluation of Hepatocellular Carcinoma Recurrence after Hepatitis C Virus Eradication by Direct-Acting Antiviral Treatment: All Kagawa Liver Disease Group (AKLDG) Study.
    Tani J, et al. Cancers (Basel). 13(9): 2257, 2021
  • Efficacy of Combined Therapy with Drug-Eluting Beads-Transcatheter Arterial Chemoembolization Followed by Conventional Transcatheter Arterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Multi-Center Study.
    Morishita A, et al. Cancers(Basel). 13(18): 4605(2021)
  • Antitumor Effect of Regorafenib on MicroRNA Expression in Hepatocellular Carcinoma Cell Lines.
    Takuma K, et al. Int J Mol Sci. 23(3): 1667(2022)
Alimentary Tract
  • Gastrointestinal Residue Removal Using a Balloon Overtube under Ultrathin Endoscopic Navigation: Ex Vivo and In Vivo Experimental Studies.
    Kozuka K, et al. J Clin Med. 10(17): 3796(2021)
  • Flexible Magnifying Endoscopy with Narrow Band Imaging for Diagnosing Uterine Cervical Neoplasms: A Multicenter Prospective Study.
    Kobara H, et al. J Clin Med. 10(20): 4753(2021)
  • Endoscopic ligation with O-ring closure for a large artificial defect after rectal endoscopic submucosal dissection.
    Tada N, et al. Dig Liver Dis. 54(1): 142-143(2022)
Pancreas & Biliary Tract
  • Correction: Endoscopic direct visualization of gallbladder polypoid lesion using peroral digital single-operator cholangioscopy.
    Kamada H, et al. Endoscopy. 53(7): C8(2021)
  • MicroRNA profiles following telmisartan treatment in pancreatic ductal adenocarcinoma cells.
    Yamana Y, et al. JCRT. 1-8(2021)
  • Telomerase Reverse Transcriptase Promoter Mutations in Human Hepatobiliary, Pancreatic and Gastrointestinal Cancer Cell Lines.
    Hirata M, et al. In Vivo. 36(1): 94-102(2022)
  • Ascending spinal tract formation in chick embryo originating from different spinal regions.
    Kokudo Y, et al. Brain Res. 1768: 147595 (2021)
  • A cerebrospinal fluid microRNA analysis: Progressive supranuclear palsy.
    Nonaka W, et al. Mol Med Rep. 25(3): 88(2022)
  • Significance of Cortical Ribboning as a Biomarker in the Prodromal Phase of Sporadic Creutzfeldt-Jakob Disease.
    Hamada Y, et al. Intern Med. Online ahead of print.

Contact Information

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