Molecular Neurobiology



Current Research Projects

  • Pathophysiology of schizophrenia and autism spectrum disorders focusing on regulation of the balance between excitation and inhibition within neural circuitry.
  • Pathophysiology of ischemic stroke focusing on elucidation of mechanism protecting the brain from acute insults.
  • Analysis of APP metabolism in a physiological condition for understanding the etiology of sporadic Alzheimer's disease.

Representative Publications

  • Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
    Takahashi N, et al. Proc. Natl. Acad. Sci. USA. 118, e2018850118 (2021).
  •  Amyloidogenic processing of amyloid β protein precursor (APP) Is enhanced in the brains of Alcadein α-deficient mice.
    Gotoh N, et al. J. Biol. Chem. 295, 9650-9662 (2020).
  • Altered cortical dynamics and cognitive function upon haploinsufficiency of the autism linked excitatory synaptic supressor MDGA2.
    Steven AC, et al. Neuron 91, 1052-1068 (2016).

Contact Information

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