Current Research Projects

Dendritic cell group
  • Analysis of the functional molecules which regulate production of type I interferons in plasmacytoid dendritic cells.
  • Study of the mechanisms regulating the function of the dendritic cell subsets.
Galectin-9 group
  • An endogenous lectin galectin-9 has been known to exert various immunomodulatory functions, which now comes to attract broader attention in medical field as one of the important player of immune-checkpoint. Our objective is to elucidate the molecular mechanism of galectin-9 in ameliorating skewed immune balance, and to explore potential therapeutic utility of the lectin for the treatment of refractory diseases including cancer and autoimmunity.

Selected Publications

Dendritic cell group
  • Transcription factor MafB-mediated inhibition of type I interferons in plasmacytoid dendritic cells.
    Saiga, H., et al. Int Immunol 34(3), 159-172 (2022).
  • The mechanism of action of Spi-B in the transcriptional activation of the interferon-alpha4 gene.
    Miyazaki, R., et al. Biochem Biophys Res Commun 525(2), 477-482 (2020).
  • Cholera toxin B induces interleukine-1beta production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.
    Orimo, T. et al. Int Immunol 31(10), 657-668 (2019).

Recent Publications

Galectin-9 group
  • Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity.
    Avtenyuk NU, et al. Biomedicines. 10, 66 (2021).
  • Plasma Levels of a Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection.
    Padilla ST, et al. Biomolecules. 10, 1495 (2020)
  • Intracellular Galectin-9 Controls Dendritic Cell Function by Maintaining Plasma Membrane Rigidity.
    Querol Cano L, et al. iScience. 22, 240-255 (2019).

Contact Information

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