Cardiovascular Physiology



Current Research Projects

  • Translational Physiology with a focus on life-style related diseases such as hypertension, atherosclerosis and obesity, as well as refractory vascular diseases such as pulmonary hypertension and cerebral vasospasm. The goal is to contribute to developing innovative new therapeutic strategies based on profound understanding of underlying pathophysiology.
  • Special interests are in the field of physiology and pathophysiology of proteinase-activated receptors, smooth muscle contraction, endothelial function, angiogenesis, metabolism and mitochondrial functions.


Representative Publications

  • Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension.
    Hiraishi K, Kurahara L-H, Feng J, Yamamura A, Cui Y, Yahiro E, Yokomise H, Go T, Ishikawa K, Yokota N, Fujiwara A, Onitsuka M, Abe K, Ohga S, Satoh T, Okada Y, Yue L, Inoue R, Hirano K.
    Transl. Res. 233, 127-143, 2021
  • Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.
    Kurahara LH, Hiraishi K, Yamamura A, Zhang Y, Abe K, Yahiro E, Aoki M, Koga K, Yokomise H, Go T, Ishikawa K, Zhang B, Kishi H, Kobayashi S, Aoki-Shoi N, Satoh T, Inoue R, Hirano K.
    J. Mol. Cell. Cardiol. 148, 50-62, 2020
  • Coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1.
    Liu W, Hashimoto T, Yamashita T, Hirano K.
    Am. J. Physiol. Cell Physiol. 316, C377-C392, 2019

Contact Information

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