Structural Biology



Current Research Projects

  • Structural studies of proteins interacting with biologically interesting carbohydrates, rare sugars, N-linked oligosaccharides, and peptidoglycan of pathogenic bacterial cell wall, based on X-ray crystallography.

Recent Publications

  • Crystal structure of a novel homodimeric L-ribulose 3-epimerase from Methylomonus sp. Yoshida H, Yoshihara A, Kato S, Mochizuki S, Akimitsu K, Izumori K, Kamitori S. FEBS Open Bio. 6:1621-1637. (2021)  doi: 10.1002/2211-5463.13159.
  • X-ray structures of Clostridium perfringens sortase C with C-terminal cell wall sorting motif of LPST demonstrate role of subsite for substrate-binding and structural variations of catalytic site. Tamai E, Sekiya H, Nariya H, Katayama S, Kamitori S.
    Biochem Biophys Res Commun. 554:138-144.  (2021) doi: 10.1016/j.bbrc.2021.03.106.
  • Structural and biochemical characterizations of the novel autolysin Acd24020 from Clostridioides difficile and its full-function catalytic domain as a lytic enzyme. Sekiya H, Tamai E, Kawasaki J, Murakami K, Kamitori S. Mol Microbiol. 115:684-698. (2021) doi: 10.1111/mmi.14636.

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