2012　論文・総説（英語） Publications（International）

1	New concepts in endothelin control of sodium balance. Nakano D, Pollck DM Clin Exp Pharmacol Physiol. 2012,39(1):104-110.
2	Salt-sensitive hypertension: Introduction Nakano D, Mori T Clin Exp Pharmacol Physiol. 2012,39(1):87-89.
3	Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice. Nakano D, Lei B, Kitada K, Hitomi H, Kobori H, Mori H, Deguchi K, Masaki T, Minamino T, Nishiyama A. Am J Hypertens. 2012 Mar;25(3):354-8.
4	Aldosterone induces insulin-like growth factor-1 receptor and hybrid receptor. Sherajee SJ, Fujita Y, Rafiq K, Nakano D, Mori H, Masaki T, Hara T, Kohno M, Nishiyama A, Hitomi H. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):257-63.
5	Activation of the aldosterone/mineralocorticoid receptor system and protective effects of mineralocorticoid receptor antagonism in retinal ischemia-reperfusion injury. Liu Y, Hirooka K, Nishiyama A, Bai L, Nakamura T, Itano T, Fujita T, Zhang J, Shiraga F. Exp Eye Res. 2012 Mar;96(1):116-23.
6	Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats. Sofue T, Kiyomoto H, Kobori H, Urushihara M, Nishijima Y, Kaifu K, Hara T, Matsumoto S, Ichimura A, Ohsaki H, Hitomi H, Kawachi H, Hayden MR, Whaley-Connell A, Sowers JR, Ito S, Kohno M, Nishiyama A. Am J Hypertens. 2012 May;25(5):604-11.
7	The optimal timing of antihypertensive medication administration for morning hypertension in patients with cerebral infarction. Hosomi N, Sueda Y, Masugata H, Dobashi H, Murao K, Ueno M, Miki T, Kohno M, Nishiyama A, Matsumoto M. Hypertens Res. 2012 Jul;35(7):720-4.
8	Angiotensin receptor blockade increases pancreatic insulin secretion and decreases glucose intolerance during glucose supplementation in a model of metabolic syndrome. Rodriguez R, Viscarra JA, Minas JN, Nakano D, Nishiyama A, Ortiz RM. Endocrinology. 2012 Apr;153(4):1684-95.
9	Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation. Rafiq K, Noma T, Fujisawa Y, Ishihara Y, Arai Y, Navi AHMN, Suzuki F, Nakano D, Hitomi H, Kitada K, Urushihara M, Kobori H, Kohno M, Nishiyama A. Circulation. 2012 Mar 20;125(11):1402-13.
10	The biphasic time course of the changes in aldosterone biosynthesis under high salt conditions in Dahl salt-sensitive rats. Morizane S, Mitani F, Ozawa K, Ito K, Matsuhashi T, Katsumata Y, Ito H, Yan X, Shinmura K, Nishiyama A, Honma S, Suzuki T, Funder JW, Fukuda K, Sano M. Arterioscler Thromb Vasc Biol. 2012 May;32(5):1194-203.
11	Role of angiotensin II-mediated AMPK inactivation on obesity-related salt-sensitive hypertension. Deji N, Kume S, Araki SI, Isshiki K, Araki H, Chin-Kanasaki M, Tanaka Y, Nishiyama A, Koya D, Haneda M, Kashiwagi A, Maegawa H, Uzu T. Biochem Biophys Res Commun. 2012 Feb 17;418(3):559-64.
12	Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4-associated oxidative stress in diabetic hamsters. Maeda Y, Inoguchi T, Takei R, Hendarto H, Ide M, Inoue T, Kobayashi K, Urata H, Nishiyama A, Takayanagi R. J Diabetes Investig. 2012 Aug 20;3(4):354-361.
13	Enhanced intrarenal receptor-mediated prorenin activation in chronic progressive anti-thymocyte serum nephritis rats on high salt intake. Huang Y, Yamamoto T, Misaki T, Suzuki H, Togawa A, Ohashi N, Fujigaki Y, Ichihara A, Nishiyama A, Senbonmatsu T, Ikegaya N, Hishida A. Am J Physiol Renal Physiol. 2012 Jul;303(1):F130-8. Epub 2012 Apr 11.
14	Liver angiotensinogen is the primary source of renal angiotensin II. Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, Nishiyama A, Ichikawa I. J Am Soc Nephrol. 2012 Jul;23(7):1181-9. Epub 2012 Apr 19.
15	Add-on aliskiren elicits stronger renoprotection than high-dose valsartan in type 2 diabetic KKAy mice that do not respond to low-dose valsartan. Lei B, Nakano D, Fan YY, Kitada K, Hitomi H, Kobori H, Mori H, Masaki T, Nishiyama A. J Pharmacol Sci. 2012 Jun 16;119(2):131-8.
16	Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels. Fujita T, Hirooka K, Nakamura T, Itano T, Nishiyama A, Nagai Y, Shiraga F. Invest Ophthalmol Vis Sci. 2012 Jun 26;53(7):4099-110. Print 2012.
17	Pre-existing arteriosclerotic intimal thickening in living-donor kidneys reflects allograft function. Sofue T, Inui M, Kiyomoto H, Moritoki M, Nishioka S, Nishijima Y, Moriwaki K, Hara T, Kushida Y, Haba R, Yoda T, Hirao T, Kakehi Y, Nishiyama A, Kohno M. Am J Nephrol. 2012 Jul 13;36(2):127-135.
18	N-type calcium channel inhibition with cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition. Lei B, Nakano D, Fujisawa Y, Liu Y, Hitomi H, Kobori H, Mori H, Masaki T, Asanuma K, Tomino Y, Nishiyama A. J Pharmacol Sci. 2012 Aug 18;119(4):359-67.
19	Elucidating mechanisms underlying altered renal autoregulation in diabetes. Takenaka T, Inoue T, Ohno Y, Miyazaki T, Nishiyama A, Ishii N, Suzuki H. Am J Physiol Regul Integr Comp Physiol. 2012 Sep;303(5):R495-504.
20	Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats. Kitada K, Nakano D, Liu Y, Fujisawa Y, Hitomi H, Shibayama Y, Shibata H, Nagai Y, Mori H, Masaki T, Kobori H, Nishiyama A. PLoS ONE. 2012;7(7):e41896. Epub 2012 Jul 24.
21	Multiphoton imaging of the glomerular permeability of angiotensinogen. Nakano D, Kobori H, Burford JL, Gevorgyan H, Seidel S, Hitomi H, Nishiyama A, Peti-Peterdi J. J Am Soc Nephrol. 2012 Nov;23(11):1847-56.
22	Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction. Salmon AH, Ferguson JK, Burford JL, Gevorgyan H, Nakano D, Harper SJ, Bates DO, Peti-Peterdi J. J Am Soc Nephrol. 2012 Aug;23(8):1339-50.
23	Aldosterone induces p21-regulated apoptosis via increased synthesis and secretion of tumour necrosis factor-α in human proximal tubular cells. Kitada K, Nakano D, Hitomi H, Kobori H, Deguchi K, Mori H, Masaki T, Nishiyama A. Clin Exp Pharmacol Physiol. 2012 Oct;39(10):858-63.
24	Angiotensin receptor blockade recovers hepatic UCP2 expression, aconitase and SDH activities, and ameliorates hepatic oxidative damage in insulin resistant rats. Montez P, Thorwald MA, Rodriguez R, Viscarra JA, Vazquez-Medina JP, Nakano D, Peti-Peterdi J, Nishiyama A, Ortiz RM. Endocrinology. 2012 Dec;153(12):5746-59.
25	Important aspects of urine sampling for angiotensinogen measurement: time and preservation conditions in healthy individuals Nishijima Y, Kobori H, Sofue T, Kaifu K, Moriwaki K, Hara T, Hitomi H, Kohno M, Nishiyama A. Tohok J Exp Med. 2012;228(4):333-9.
25	Quantitative Spectroscopic Tomography for the Non-invasive Measurement of the Biogenic-substances Wei Qi, Daisuke Kojima, Shun Sato, Satoru Suzuki, Pradeep K. W. Abeygunawardhana, Akira Nishiyama, Ichirou Ishimaru MECATRONICS REM. 2012 ;280 - 285
26	The wide-field Fourier spectroscopic-imaging of the radiation heat from the object itself in the middle infrared region for the health monitoring Wei Qi, Takashi Takuma, Asuka Inui, Ryosuke Tsutsumi, Takehiko Yuzuriha, Hiroyasu Kagiyama, Daisuke Kojima, Akira Nishiyama, Ichirou Ishimaru OPTICAL DIAGNOSTICS AND SENSING XII: TOWARD POINT-OF-CARE DIAGNOSTICS; AND DESIGN AND PERFORMANCE VALIDATION OF PHANTOMS USED IN CONJUNCTION WITH OPTICAL MEASUREMENT OF TISSUE IV 8229
27	Spectroscopic tomography of biological tissues with the near-infrared radiation for the non-invasive measurement of the biogenic-substances Daisuke Kojima, Takashi Takuma, Asuka Inui, Wei Qi, Ryosuke Tsutsumi, Takehiko Yuzuriha, Hiroyasu Kagiyama, Akira Nishiyama, Ichirou Ishimaru OPTICAL DIAGNOSTICS AND SENSING XII: TOWARD POINT-OF-CARE DIAGNOSTICS; AND DESIGN AND PERFORMANCE VALIDATION OF PHANTOMS USED IN CONJUNCTION WITH OPTICAL MEASUREMENT OF TISSUE IV 8229
28	Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor. Shamshad J Sherajee, Yoshiko Fujita, Kazi Rafiq, Daisuke Nakano, Hirohito Mori, Tsutomu Masaki, Taiga Hara, Masakazu Kohno, Akira Nishiyama, Hirofumi Hitomi Arteriosclerosis, thrombosis, and vascular biology 32(2) 257 - 63 2012 Feb
29	Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3. Kazunori Inoue, Isao Matsui, Takayuki Hamano, Naohiko Fujii, Akihiro Shimomura, Chikako Nakano, Yasuo Kusunoki, Yoshitsugu Takabatake, Michinori Hirata, Akira Nishiyama, Yoshiharu Tsubakihara, Yoshitaka Isaka, Hiromi Rakugi LABORATORY INVESTIGATION 92(12) 1686 - 1697 2012 Dec.
30	Angiotensin II receptor blocker improves salt sensitivity of blood pressure and renal nitric oxide synthesis in type 2 diabetic patients with microalbuminuria. Okada N, Konishi Y, Morikawa N, Maeda I, Kitabayaashi C, Masada N, Shirahashi N, Willcos CS, NISHIYAMA Akira, Imanishi M J Renin Angiotensin Aldosterone Syst. 2012 May.
31	Activation of JNK Triggers Release of Brd4 from Mitotic Chromosomes and Mediates Protection from Drug-Induced Mitotic Stress. Akira Nishiyama, Anup Dey, Tomohiko Tamura, Minoru Ko, Keiko Ozato PLOS ONE 7(5) 2012 May.
32	Enriched Cholesterol Diet Increases Expression of Renal Epithelial Na+ Channel Gamma Subunit in Rats. Jessica Sood, Shaina Balayan, Jacqueline N. Minas, Ruben Rodriguez, Jennifer Aguil, Daisuke Nakano, Akira Nishiyama, Mouhamed S. Awayda, Rudy Ortiz. FASEB JOURNAL 26 2012 Apr.
33	Decreased Pancreatic Insulin Secretion is associated with increased AT1 Activation during Glucose Supplementation in a Model of Metabolic Syndrome. Ruben Rodriguez, Jose A. Viscarra, Jacqueline N. Minas, Andrew Lee, Daisuke Nakano, Akira Nishiyama, Rudy M. Ortiz FASEB JOURNAL 26 2012 Apr.
34	High Dietary Glucose Intake Increases Hepatic Triglyceride Content and Oxidative Stress: Contributions of Angiotensin Receptor. Priscilla Montez, Thorwald A. Max, Ruben Rodriguez, Jose Viscarra, Jose Pablo Vazquez-Medina, Daisuke Nakano, Akira Nishiyama, Rudy M. Ortiz FASEB JOURNAL 26 2012 Apr.
35	AT1 blockade decreases NADPH oxidase 2 content and increases insulin signaling in a model of insulin resistance. Irina Popovich, Ruben Rodriguez, Jose Viscarra, Jose-Pable Vasquez-Medina, Akira Nishiyama FASEB JOURNAL 26 2012 Apr.
36	Aldosterone induces apoptosis of proximal tubular cells through p21/TNF alpha-dependent pathway. Kento Kitada, Daisuke Nakano, Junichi Yatabe, Hirofumi Hitomi, Hiroyuki Kobori, Akira Nishiyama JOURNAL OF PHARMACOLOGICAL SCIENCES 118 93P - 93P 2012
37	Glomerular mineralocorticoid receptor activation limits the benefits of salt reduction in Dahl salt-sensitive rats. Daisuke Nakano, Kento Kitada, Ya Liu, Yoshihide Fujisawa, Hirofumi Hitomi, Hiroyuki Kobori, Akira Nishiyama JOURNAL OF PHARMACOLOGICAL SCIENCES 118 93P - 93P 2012
38	Chronic measurement of renal sympathetic nerve activity (RSNA) in rats by using a telemetry system. Naoki Kondo, Yoshihide Fujisawa, Masako Fujita, Hiroko Nogami, Kazuyo Kawakami, Masahiro Moritoki, Satoru Nishioka, Yoko Nishijima, Tadashi Sofue, Kumiko Kaifu, Taiga Hara, Kento Kitada, Daisuke Nakano, Masakazu Kono, Akira Nishiyama JOURNAL OF PHARMACOLOGICAL SCIENCES 118 93P - 93P 2012
39	p21 is central regulator for the development of cell senescence in diabetic proximal tubules. Kento Kitada, Daisuke Nakano, Junichi Yatabe, Hirofumi Hitomi, Hiroyuki Kobori, Akira Nishiyama JOURNAL OF PHARMACOLOGICAL SCIENCES 118 71P - 71P 2012
40	Effects of anesthetic agents on renal sympathetic nerve activity in a freely moving conscious rat. Yoshihide Fujisawa, Naoki Kondo, Yukiko Nagai, Daisuke Nakano, Akira Nishiyama JOURNAL OF PHARMACOLOGICAL SCIENCES 118 239P - 239P 2012
41	Association between cardiac function and pulmonary function in hypertensive patients. Masugata H, Senda S, Okada H, Murao K, Hitomi H, Hosomi N, Murakami K, Noma T, Nishiyama A, Kohno M Department of Integrated Medicine 40(1) 105 - 114 2012