2011　論文・総説（英語） Publications（International）

1	Urinary angiotensinogen reflects the activity of intrarenal renin-angiotensin system in patients with IgA nephropathy. Nishiyama A, Konishi Y, Ohashi N, Morikawa T, Urushihara M, Maeda I, Hamada M, Kishida M, Hitomi H, Shirahashi N, Kobori H, Imanishi M. Nephrol Dial Transplant. 2011 Jan;26(1):170-7.
2	Programmed 11-βhydroxysteroid dehydrogenase type 2 reduction: a possible cause of adult-onset disease? Nakano D, Nishiyama A. J. Hypertens. 2011Feb;29(2):201-3.
3	Renin-angiotensin system in the kidney and oxidative stress: Local renin-angiotensin-aldosterone system and NADPH oxidase-dependent oxidative stress in the kidney. Kiyomoto H, Kobori H, Nishiyama A. Studies On Renal Disorders. Oxidative stress in applied basic research and clinical practice. 2011, Part 1, 71-91. Humana Press.
4	Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats. Rafiq K, Nakano D, Hitomi H, Ihara G, Nagai Y, Fujisawa Y, Ohashi N, Kobori H, Kiyomoto H, Kohno M, Nishiyama A. J. Hypertens. 2011Feb;29(2):290-8.
5	Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney. Rafiq K, Hitomi H, Nakano D, Nishiyama A. J. Pharmacol. Sci. 2011;115(1):1-7.
6	Aldosterone/mineralocorticoid receptor stimulation induces cellular senscence in the kidney. Fan YY, Kohno M, Hitomi H, Kitada K, Fujisawa Y, Yatabe J, Yatabe M, Felder RA, Ohsaki H, Rafiq K, Sherajee SJ, Noma T, Nishiyama A, Nakano D. Endocrinology. 2011 Feb;152(2):680-8.
7	Rare sugar d-psicose improves insulin sensitivity and glucose tolerance in type-2 diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Tokuda M, Hossain MA, Kitagaki S, Nakano D, Nishiyama A, Funamoto Y, Matsunaga T, Tsukamoto I, Yamaguchi F, Kamitori K, Dong Y, Hirata Y, Murao K, Toyoda Y. Biochem Biophys Res Commun. 2011 Feb 4;405(1):7-12.
8	Blockade of AT1 receptors protects the blood-brain barrier and improves cognition in Dahl salt-sensitive hypertensive rats. Pelisch N, Hosomi N, Ueno M, Nakano D, Hitomi H, Mogi M, Shimada K, Kobori H, Horiuchi M, Sakamoto H, Matsumoto M, Kohno M, Nishiyama A. Am J. Hypertens. 2011 Mar;24(3):362-8.
9	Angiotensin II induces human astrocyte senecence through reactive oxygen species production. Liu G, Hosomi N, Hitomi H, Pelish N, Fu H, Masugata H, Murao K, Ueno M, Matsumoto M, Nishiyama A. Hypertens.Res. 2011 Apr;34(4):479-83.
10	Blood glucose level and survival in streptozotocin-treated human chymase transgenic mice. Rafiq K, Sherajee SJ, Fan YY, Fujisawa Y, Takahashi Y, Matsuura J, Hase N, Urata H, Nakano D, Hitomi H, Nishiyama A. Chinese J Physiol. 2011 Feb 28;54(1):30-5.
11	Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via EGF receptor-mediated ERK and Akt activation pathway. Liu G, Hitomi H, Nosomi N, Shibayama Y, Nakano D, Kiyomoto H, Ma H, Yamaji Y, Kohno M, Ichihara A, Itoh H, Nishiyama A. J. Hypertens. 2011 Apr;29(4):696-705.
12	Mechanism underlying the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertention. Yamada Y, Tsuboi K, Hattori T, Murase T, Ohtake M, Furukawa M, Ueyama J, Nishiyama A, Murohara T, Nagata K. Hypertens. Res. 2011 Jul;34(7):809-16.
13	Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension. Ryuzaki M, Ichihara A, Ohshima Y, Sakoda M, Kurauchi-Mito A, Narita T, Kinouchi K, Murohashi-Bokuda K, Nishiyama A, Itoh H. Hypertens. Res. 2011 Mar;34(3):301-7.
14	Possible involvement of the (pro)renin receptor-dependent system in the development of insulin resistance. Rafiq K, Hitomi H, Nakano D, Ichihara A, Nishiyama A. Front Biosci. 2011 Jun 1;3:1478-85.
15	Frontiers in Research: Chronic Kidney Disease Introduction: hearing footsteps of the future. Nangaku M, Nishiyama A. Clin Exp Pharmacol Physiol. 2011 Jul;38(7):388-90.
16	Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats. Fujisawa Y, Nagai Y, Lei B, Nakano D, Fukui T, Hitomi H, Mori H, Masaki T , Nishiyama A. Hypertens. Res. 2011 Nov;34(11):1228-32.
17	The proximal tubular renin-angiotensin system during albuminuria. Nakano D, Nishiyama A. J.Hypertens. 2011 Jul;29(7):1292-4.
18	The role of incretins in salt-sensitive hypertension: the potential use of DPP-IV inhibitors. Tanaka T, Nangaku M, Nishiyama A. Cur Opin Nephrol Hytertens. 2011 Sep;20(5):476-81.
19	Relationship between urinary angiotensinogen and salt sensitivity of blood pressure in patients with IgA nephropathy. Konishi Y, Nishiyama A, Morikawa T, Kitabayashi C, Shibata M, Hamada M, Kishida M, Hitomi H, Kiyomoto H, Miyashita T, Mori M, Urushihara M, Kobori H, Imanishi M. Hypertension. 2011 Aug;58(2):205-11.
20	Angiotensin II shifts insulin signaling into vascular remodeling from glucose metabolism in vascular smooth muscle cells. Hitomi H, Kaifu K, Fujita Y, Sofue T, Nakano D, Moriwaki K, Hara T, Kiyomoto H, Kohno M, Kobori H, Nishiyama A. Am J Hypertens. 2011 Oct;24(10):1149-55.
21	Angiotensin II type 1 receptor blockade suppresses glomerular renin-angiotensin system activation, oxidative stress, and progressive glomerular injury in rat anti-glomerular basement membrane glomerulonephritis. Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, Shimizu M, Nishiyama A, Kawachi H, Kagami S. Translational Res. 2011 Oct;158(4):235-48.
22	Effect of efonidipine on TGF-β1-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts. Lei B, Hitomi H, Mori T, Nagai Y, Deguchi K, Mori H, Masaki T, Nakano D, Kobori H, Kitaura Y, Nishiyama A. J Pharmacol Sci. 2011 Oct 17;117(2):98-105. Epub 2011 Sep 7.
23	Therapeutic effects of post-ischemic treatment with hypotensive doses of an angiotensin II receptor blocker on transient focal cerebral ischemia. Fu H, Hosomi N, Pelisch N, Nakano D, Liu G, Ueno M, Miki T, Masugata H, Sueda Y, Itano T, Matsumoto M, Nishiyama A, Kohno M. J Hypertens. 2011 Nov;29(11):2210-2219.
24	Chronic angiotensin receptor blockade suppresses intracardiac angiotensin II in angiotensin II-infused rats. Conte D, Viscarra J, Nishiyama A, Ortiz RM. Exp Biol Med. 2011 Dec 1;236(12):1449-53. Epub 2011 Nov 15.
25	Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor. Liu G, Hitomi H, Hosomi N, Lei B, Nakano D, Deguchi K, Mori H, Masaki T, Ma H, Griendling KK, Nishiyama A. Exp Cell Res. 2011 Oct 15;317(17):2420-8.
26	Short-term calorie restriction in early life attenuates the development of proteinuria but not glucose intolerance in type 2 diabetic OLETF rats. Nakano D, Diah S, Kitada K, Hitomi H, Mori H, Masaki T, Kobori H, Nishiyama A ISRN Endocrinology. 2011;2011:768637.
27	Subdose of fasudil suppresses myocardial fibrosis in aldosterone-salt-treated uninephrectomized rats. Guo P, Wu C, Masaki T, Mori H, Nishiyama A Pharmazie. 66:716-719, 2011. Pharmazie. 66:716-719, 2011.
28	The Reduction of Prorenin Levels by Diet and Exercise Therapies Using Telemedicine Ameliorates Insulin Resistance in Patients With Metabolic Syndrome. Hideyasu Kiyomoto, Atsuhiro Ichihara, Michiaki Abe, Takefumi Mori, Akira Nishiyama, Sadayoshi Ito HYPERTENSION 58(5) E73 - E73 2011 Nov.
29	Introduction: Hearing footsteps of the future. Masaomi Nangaku, Akira Nishiyama. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 38(7) 388 - 390 2011 Jul.
30	Potential Role of the Epithelial Na plus Channel alpha Subunit Cleavage in the Regulation of Urinary Na plus Excretion During Insulin Resistance. Shaina S. Balayan, Ruben Rodriguez, Jose Viscarra, Akira Nishiyama, Mouhamed S. Awayda, Rudy M. Ortiz FASEB JOURNAL 25 2011 Apr.
31	Angiotensin Receptor Blockade Decreases Hepatic Triglyceride Content and Reduces Retroperitoneal Fat Deposition Following Increased Glucose Intake in a Model of Metabolic Syndrome. Priscilla Montez Montez, Ruben Rodriguez, Jose Viscarra, Daisuke Nakano, Akira Nishiyama, Rudy M. Ortiz. FASEB JOURNAL 25 2011 Apr.
32	Chronic Blockade of the Renin-Angiotensin System Improves Glucose Tolerance in Insulin Resistant Rats. Ruben Rodriguez, Jacqui Minas, Jennifer Aguil, Daisuke Nakano, Akira Nishiyama, Rudy Martin Ortiz FASEB JOURNAL 25 2011 Apr.
33	Blockade of Angiotensin Receptor Ameliorates Insulin Resistance and Suppresses Plasma Leptin in OLETF Rats Supplemented with High Glucose. Jennifer Denyse Aguil, Ruben Rodriguez, Jose Viscarra, Jacqueline Minas, Daisuke Nakano, Akira Nishiyama, Rudy Ortiz. FASEB JOURNAL 25 2011 Apr.
34	Angiotensin and Mineralocorticoid Receptor Antagonism Combined Improves Urinary 8-Isoprostane Excretion in Ang II-Infused Rats. Debra A. Conte, Jacqueline N. Minas, Jennifer Aguil, Akira Nishiyama, Rudy M. Ortiz FASEB JOURNAL 25 2011 Apr.
35	Intracardiac Angiotensin II Is Not Modified By A Cholesterol Enriched Diet. Jacqueline Norma Minas, Ruben Rodriguez, Jennifer Aguil, Daisuke Nakano, Akira Nishiyama, Rudy M. Ortiz. FASEB JOURNAL 25 2011 Apr.
36	Contribution of (Pro)renin Receptor to the Development of Nephropathy in Diabetic Stroke-Prone Spontaneously Hypertensive Rats. Yasufumi Seki, Atsuhiro Ichihara, Yuki Mizuguchi, Mariyo Sakoda, Asako Mito, Tatsuya Narita, Kenichiro Kinouchi, Akira Nishiyama, Hiroshi Itoh CLINICAL AND EXPERIMENTAL HYPERTENSION 33(1) 21 - 21 2011.
37	Temocapril does not suppress renal angiotensin II level in angiotensin I-infused rats. Keisuke Onishi, Miki Murase, Daisuke Nakano, Kento Kitada, Hirofumi Hitomi, Akira Nishiyama. JOURNAL OF PHARMACOLOGICAL SCIENCES 115 151P - 151P, 2011.
38	Insulin treatment prevents renal senescence in diabetes. Kento Kitada, Daisuke Nakano, Hirofumi Hitomi, Akira Nishiyama. JOURNAL OF PHARMACOLOGICAL SCIENCES 115 64P - 64P 2011.
39	The Effect of Pre-Diabetic High Calorie Diet or Calorie Restriction in OLETF Rats. Suwarni Diah, Daisuke Nakano, Akira Nishiyama. CLINICAL AND EXPERIMENTAL HYPERTENSION 33(1) 12 - 12 2011.
40	Angiotensin II induces podocyte apoptosis through the activation of Na+/H+ exchanger-1 and oxidative stress. Ya Liu, Hirofumi Hitomi, Suwarni Diah, Daisuke Nakano, Akira Nishiyama JOURNAL OF PHARMACOLOGICAL SCIENCES 115 108P - 108P 2011.
41	Intrarenal Renin-Angiotensin System during the Development of Renal Injury in Otsuka-Long-Evans-Tokushima-Fatty Rats. Akira Nishiyama, Masahito Imanishi, Hiroyuki Kobori. CLINICAL AND EXPERIMENTAL HYPERTENSION 33(1) 3 - 3 2011.