2010 論文・総説(英語) Publications(International)

1 Expression and localization of 11beta-hydroxysteroid dehydrogenase in the rats endolymphatic sac.
Akiyama K, Miyashita T, Matsubara A, Inamoto R, Mori T, Nishiyama A, Mori N.
Acta Otolaryngologica. 2010 Feb;130(2):228-32.
2 Involvement of mineralocorticoid receptor in high glucose-induced big mitogen-activated protein kinase 1 activation and mesangial cell proliferation.
Liu G, Miyata K, Hitomi H, Yao L, Sun GP, Suzaki Y, Hosomi N, Kiyomoto H, Nakano D, Tamaki T, Yoshizumi M, Nishiyama A.
J. Hypertens. 2010 Mar;28(3):536-42.
3 Mineralocorticoid receptor blockade enhances the anti-proteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats.
Nishiyama A, Kobori H, Konishi Y, Morikawa T, Maeda I, Okumura M, Kishida M, Hamada M, Nagai Y, Nakagawa T, Ohashi N, Nakano D, Hitomi H, Imanishi M.
J. Pharmacol. Exp. Ther. 2010 Mar;332(3):1072-80.
4 Systemic candesartan reduces brain angiotensin II via downregulation of brainrenin-angiotensin system.
Pelisch N, Hosomi N, Ueno M, Masugata H, Murao K, Hitomi H, Nakano D, Kobori H, Nishiyama A, Kohno M.
Hypertens Res. 2010 Feb;33(2):161-164.
5 Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats; possible involvement of N-type calcium channel in podocyte.
Fan Y-Y, Kohno M, Nakano D, Ohsaki H, Kobori H, Diah S, Ohashi N, Hitomi H, Asanuma K, Noma T, Tomino Y, Fujita T, Nishiyama A.
J. Hypertens. 2010 May;28(5):1034-43.
6 Echocardiographic assessment of the cardio-renal connection: is left ventricular hypertrophy or diastolic function more closely correlated with estimated glomerular filtration rate in patients with cardiovascular risk factors?
Masugata H, Senda S, Goda F, Yamagami A, Okuyama H, Kohno T, Hosomi N, Yukiiri K, Noma T, Imai M, Kiyomoto H, Nishiyama A, Kohno M.
Clin Exp Hypertens. 2010 Jan;32(2):113-20.
7 Role of caveolin and Hsp70 interaction in the antioxidative effects of an ARB in SHR proximal tubules.
Nishiyama A, Hitomi H.
J. Hypertens. 2010 Jan;20(1):9-12.
8 Role of (pro)renin receptor in cardiovascular cells from the aspect of signaling.
Hitomi H, Liu G, Nishiyama A.
Front Biosci. 2010 Jun 1;2:1246-9
9 Association between YKL-40 and adult primary astrocytoma.
Zhang W, Kawanishi M, Miyake K, Kagawa M, Kawai N, Murao K, Nishiyama A, Fei Z, Zhang X, Tamiya T.
Cancer. 2010 Jun 1;116(11):2688-97.
10 Prorenin/renin and insulin resistance.
Rafiq K, Nagai Y, Nakano D.
Front Biosci 2010 Jun 1;2:1143-6.
11 Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes.
Sakoda M, Ichihara A, Kurauchi-Mito A, Narita T, Kinouchi K, Murohashi-Bokuda K, Saleem MA, Nishiyama A, Suzuki F, Itoh H.
Am J Hypertens. 2010 May;23: 575-580.
12 New approaches to blockade of the renin-angiotensin-aldosterone system: Overview of the regulation of the renin-angiotensin-aldosterone system.
Nishiyama A, Mitsuyama-Kim S.
J. Pharmacol. Sci. 2010;113(4):289-91.
13 New approaches to blockade of the Renin-Angiotensin-Aldosterone system: Mineralocorticoid receptor blockers exert antihypertensive and renoprotective effects independently of the renin-angiotensin system.
Nishiyama A, Hasegawa K, Diah S, Hitomi H.
J. Pharmacol. Sci. 2010;113(4):310-4.
14 Regression of superficial glomerular podocyte injury in type 2 diabetic rats with overt albuminuria : effect of angiotensin II blockade.
Ihara G, Kiyomoto H, Kobori H, Nakai Y, Ohashi N, Hitomi H, Nakano D, Pelisch N, Hara T, Mori T, Ito S, Kohno M, Nishiyama A.
J. Hypertens. 2010 Nov;28(11):2289-98.
15 Mechanical stretch potentiates angiotensin II-induced proliferation in spontaneously hypertensive rat vascular smooth muscle cells.
Liu G, Hitomi H, Hosomi N, Lei B, Pelish N, Nakano D, Kiyomoto K, Ma H, Nishiyama A.
Hyperyens. Res. 2010 Dec;33(12):1250-7.
16 Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters.
Maeda Y, Inoguchi T, Takei R, Sawada F, Sasaki S, Fujii M, Kobayashi K, Urata H, Nishiyama A, Takayanagi R.
Am J. Physiol. Renal Physiol. 2010 Dec;299(6):F1328-38.
17 [Calcium antagonists: current and future applications based on new evidence. Effects of calcium channel blockers on oxidative stress].
Akira Nishiyama, Daisuke Nakano, Hirofumi Hitomi
Clinical calcium 2010 Jan; 20(1) 38 - 44
18 Aliskiren Suppressed the Development of Renal Injury in valsartan-Treated Kkay Mice.
Bai Lei, Fan Yu-Yan, Daisuke Nakano, Hirofumi Hitomi, Akira Nishiyama.
HYPERTENSION 56(5) E129 - E130.
19 Augmented Intrarenal Angiotensinogen mRNA Expression Parallels Renal Dysfunction in Patients with Type 2 Diabetes.
Masumi Kamiyama, Maki Urushihara, Takashi Morikawa, Yoshio Konishi, Masahito Imanishi, Akira Nishiyama, Hiroyuki Kobori
HYPERTENSION 56(5) E135 - E135
20 Angiotensin II but not Aldosterone Increased Renal P21 Expression in Angiotensin II-Salt Model.
Daisuke Nakano, Bai Lei, Kento Kitada, Hirofumi Hitomi, Akira Nishiyama.
HYPERTENSION 56(5) E161 - E161.
21 Rare Sugar D-Psicose Ameliorates Glucose Intolerance through Glucokinase Activation in the Liver and Suppression of Pancreatic Islet Injury in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Mohammad A. Hossain, Fuminori Yamaguchi, Shigeru Kitagaki, Daisuke Nakano, Akira Nishiyama, Koji Murao, Toshihiko Ishida, Yukiyasu Toyoda, Masaaki Tokuda
DIABETES 59 A682 - A683
22 Suppression of blood glucose levels by D-psicose in glucose tolerance test in diabetic rats.
Yukiyasu Toyoda, Shigeaki Mori, Noriko Umemura, Yuriko Futamura, Hiroki Inoue, Tsuyoshi Hata, Ichitomo Miwa, Koji Murao, Akira Nishiyama, Masaaki Tokuda.
Japanese Pharmacology and Therapeutics 38 261 - 269.
23 Blockade of the Renin-Angiotensin System Improves Glucose Intolerance in Pre-diabetic Rats on a High Glucose Diet.
Ruben Rodriguez, Jose Viscarra, Daisuke Nakano, Akira Nishiyama, Rudy M. Ortiz
FASEB JOURNAL 24
24 Ameliorative effect of a rare sugar D-psicose on glucose intolerance in type 2 diabetic rat model.
Mohammad A. Hossein, Fuminori Yamaguchi, Shigeru Kitagaki, Akira Nishiyama, Koji Murao, Toshihiko Ishida, Yukiyasu Toyoda, Masaaki Tokuda.
JOURNAL OF PHYSIOLOGICAL SCIENCES 60 S96 - S96.
25 Childhood calorie restriction attenuates the development of proteinuria but not insulin resistance in OLETF rats .
Daisuke Nakano, Suwarni Diah, Hirofumi Hitomi, Akira Nishiyama
JOURNAL OF PHARMACOLOGICAL SCIENCES 112 94P - 94P
26 Role of renal afferent nerve activity in the regulation of cardiovascular dynamics in rats.
Yosihide Fujisawa, Yukiko Nagai, Daisuke Nakano, Shoji Kimura, Hirofumi Hitomi, Akira Nishiyama.
JOURNAL OF PHARMACOLOGICAL SCIENCES 112 96P - 96P.
27 The Link between oxidative stress and Na+/Ca2+ exchanger in aldosterone-induced cardiac remodeling.
Takuya Iyoda, Satomi Kita, Shintaro Yamamoto, Issei Komuro, Akira Nishiyama, Takahiro Iwamoto
JOURNAL OF PHARMACOLOGICAL SCIENCES 112 95P - 95P