2009　論文・総説（英語） Publications（International）

1	Masugata H, Senda S, Okuyama H, Murao K, Inukai M, Hosomi N, Yukiiri K, Nishiyama A, Kohno M, Goda F. Comparison of central blood pressure and cardio-ankle vascular index for association with cardiac function in treated hypertensive patients. Hypertens Res. 2009 Dec;32(12):1136-42.
2	Nishiyama A, Hitomi H, Rahman A, Kiyomoto H. Drug Discovery of Overcoming Chronic Kidney Disease (CKD):Pharmacological Effects of Mineralocortcoid-Receptor Blockers. J Pharmacol Sci. 2009;109(1):1-6.
3	Hosojima M, Sato H, Yamamoto K, Kaseda R, Soma T, Kobayashi A, Suzuki A, Kabasawa H, Takeyama A, Ikuyama K, Iino N, Nishiyama A, Thekkumkara TJ, Takeda T, Suzuki Y, Gejyo F, Saito A. Regulation of megalin expression in cultured proximal tubule cells by angiotensin II type 1A receptor and insulin-mediated signaling cross-talk. Endocrinology. 2009 Feb;150(2):871-8.
4	Kaifu K, Kiyomoto K, Hitomi, H Matsubara K, Hara T, Moriwaki K, Ihara G, Fujita Y, Sugasawa N, Nagata D, Nishiyama A, Kohno M. Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells. Nephrol Dial Transplant. 2009 Mar;24(3):809-15.
5	Hirata K, Kume S, Araki SI, Sakaguchi M, Chin-Kanasaki M, Isshiki K, Sugimoto T, Nishiyama A, Koya D, Haneda M, Kashiwagi A, Uzu T. Expending-4 has an anti-hypertensive effect in salt-sensitive mice model. Biochemi Biophys Res Commun. 2009 Feb 27;380(1):44-9.
6	Tsugita M, Iwasaki Y, Nishiyama M, Taguchi T, Shinahara M, Taniguchi Y, Kambayashi M, Nishiyama A, Gomez-Sanchez CE, Terada Y, Hashimoto K. Glucocorticoid receptor plays an indispensable role in mineralocorticoid receptor-dependent transcription in GR-deficient BE(2)C and T84 cells in vitro. Mol Cell Endocrinol. 2009 Apr 10;302(1):18-25.
7	Masugata M, Senda S, Goda F, Yamagami A, Okuyama H, Kohno T, Hosomi N, Yukiiri K, Noma T, Kiyomoto H, Murao K, Nishiyama A, Kohno M. Tissue Doppler echocardiography for predicting arterial stiffness assessed by cardio-ankle vascular index. Tohoku J Exp Med. 2009 Feb;217(2):139-46.
8	Ueno M, Wu B, Nishiyama A, Huang CL, Hosomi N, Kusaka T, Nakagawa T, Onodera M, Kido M, Sakamoto H. The expression of matrix metalloproteinase-13 is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model. Hypertens Res. 2009 May:32(5):332-8.
9	Hobo A, Yuzawa Y, Kosugi T, Kato N, Asai N, Sato W, Maruyama S, Ito Y, Kobori H, Ikematsu S, Nishiyama A, Matsuo S, Kadomatsu K. The growth factor midkine regulates the renin-angiotensin system in mice. J. Clin. Invest. 2009 Jun;119(6):1616-25.
10	Lu XM, Zhang GX, Yu YQ, Kimura S, Nishiyama A, Matsuyoshi H, Shimizu J, Takaki M. The opposite roles of nNOS in cardiac ischemia-reperfusion-induced injury and in ischemia preconditioning-induced cardioprotection in mice. J Physiol Sci. 2009 Jul;59(4):253-62.
11	Fan Y, Kohno M, Nakano D, Hitomi H, Nagai Y, Fujisawa Y, Lu XM, Fu K, Du J, Ohmori K, Hosomi N, Kimura S, Kiyomoto H, Nishiyama. Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats. J Hypertension. 2009 Sep;27(9):1855-62.
12	Nagai Y, Ichihara A, Nakano D, Kimura S, Pelisch N, Fujisawa Y, Hitomi H, Hosomi N, Kiyomoto H, Kohno M, Ito H, Nishiyama A. Possible contribution of the nonproteolytic activation of prorenin to the development of insulin resistance in fructose-fed rats. Exp. Physiol. 94:1016-1023,2009.
13	Du J, Fan Y-Y, Hitomi H, Kiyomoto H, Kimura S, Kong C-Z, Noma T, Kohno M, Nishiyama A, Nakano D. Mineralocorticoid receptor blockade and calcium channel blockade have different renoprotective effects on glomerular and interstitial injury in rats. Am. J. Physiol. Renal Physiol. 2009 Sep;297(3):F802-8. Epub 2009 Jun 17
14	Ogawa S, Kobori H, Ohashi N, Urushihara M, Nishiyama A, Mori T, Ishizuka T, Nako K, Ito S. Angiostensin II type 1 receptor blockers reduce urinary angiotensinogen excretion and the levels of urinary markers of oxidative stress and inflammation in patients with type 2 diabetic nephropathy. Biomarker Insights. 2009 Jun 23;4:97-102.
15	Hara T, Kiyomoto H, Hitomi H, Moriwaki K, Ihara G, Kaifu K, Fujita Y, Higashiyama C, Nishiyama A, Kohno M. Low-density lipoprotein apheresis for hemodialysis patients with peripheral arterial disease reduces reactive oxygen species production via suppression of NADPH oxidase gene expression in leukocytes. Nephrol. Dial. Transplant. 2009, 24(12):3818-25,2009
16	Yoshida A, Noda T, Tani M, Oyama T, Watanabe Y, Kiyomoto H, Nishiyama A. The role of basic fibroblast growth factor to enhance fetal intestinal mucosal cell regeneration in vivo. Pediatr. Surg. Int. 2009, Avgi 25(8):691-5.
17	Nishiyama A, Matsusaka T, Miyata T. Angiotensin Ⅱ type 1A receptor deficiency and longevity. Nephrol. Dial. Transplant. 24:3280-3281, 2009
18	Masugata H, Senda S, Goda F, Yamagami A, Okuyama H, Kohno T, Hosomi N, Yukiiri K, Noma T, Murao K, Nishiyama A, Kohno M. Independent determinants of the tei index in hypertensive patients with preserved left ventricular systolic function. Int. Heart J.　50: 331-340, 2009
19	Fan YY, Nishiyama A, Fujisawa Y, Kobori H, Nakano D, Matsuura J, Hase N, Hitomi H, Kiyomoto H, Urata H, Kohno M. Contribution of chymase-dependent Angiotensin II formation to the progression of tubulointerstitial fibrosis in obstructed kidneys in hamsters. J. Pharmacol. Sci. 2009 Sep;111(1):82-90.
20	Nakajima-Takenaka C, Zhang G-X, Obata K, Tohne K, Matsuyoshi H, Nagai Y, Nishiyama A, Takaki M. Left ventricular function of isoproterenol-induced hypertrophied rat hearts perfused with blood: mechanical work and energies. Am. J. Physiol. Heart. Circ. Physiol. 297:H1736-H1743, 2009
21	Kazi Rafiq, Shamshad J. Sherajee, Akira Nishiyama, M. A. Sufiun, Mahbub Mostofa. Effects of indigenous medicinal plants of Bangladesh on blood glucose level and neuropathic pain in streptozotocin-induced diabetic rats. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 3(12) 636 - 642 2009.
22	Yoshihide Fujisawa, Yukiko Nagai, Daisuke Nakano, Shoji Kimura, Hirofumi Hitomi, Akira Nishiyama. Effect of intrarenal stimulation by increasing of ureteral pressure on cardiovascular hemodynamics in rat treated with high salt. JOURNAL OF PHARMACOLOGICAL SCIENCES 109 263P - 263P 2009.
23	Y. Seki, A. Ichihara, M. Sakoda, Y. Mizuguchi, A. Mito, T. Narita, K. Kinouchi, A. Nishiyama, H. Itoh. Involvement of Angiotensin II Generation and Intracellular Signal Transduction by (Pro)renin Receptor in Cardiac Hypertrophy of Diabetic Spontaneous Hypertensive Rats Complicated with Diabetes. CLINICAL AND EXPERIMENTAL HYPERTENSION 31(6) 498 - 498 2009.
24	Hirofumi Hitomi, Gang Liu, Naohisa Hosomi, Hideyasu Kiyomoto, Daisuke Nakano, Shoji Kimura, Masakazu Kohno, Akira Nishiyama. MECHANICAL STRETCH POTENTIATES ANGIOTENSIN II-INDUCED PROLIFERATION IN SPONTANEOUSLY HYPERTENSIVE RAT VASCULAR SMOOTH MUSCLE CELLS . JOURNAL OF VASCULAR RESEARCH 46 152 - 152 2009.
25	Akira Nishiyama, Daisuke Nakano, Hirofumi Hitomi. Mineralocorticoid receptor antagonists as a treatment paradigm for cardiovascular and kidney diseases. JOURNAL OF PHARMACOLOGICAL SCIENCES 109 18P - 18P 2009.
26	Bai Lei, Tatsuhiko Mori, Hirofumi Hitomi, Daisuke Nakano, Shoji Kimura, Akira Nishiyama. EFFECT OF EFONIDIPINE ON TGF-beta 1-INDUCED PROLIFERATION VIA SMAD2/3 DEPENDENT PATHWAY IN RAT CARDIAC FIBROBLASTS. JOURNAL OF PHYSIOLOGICAL SCIENCES 59 314 - 314 2009.
27	Daisuke Nakano, Akira Nishiyama, David Pollock. ETA-dependent natriuresis in renal medulla. JOURNAL OF PHARMACOLOGICAL SCIENCES 109 135P - 135P 2009.