LINTRE

Software for testing the molecular clock and making linearized trees

What does LINTRE do?

The LINTRE programs are for (1) testing the molecular clock on a given topology of a phylogenetic tree and (2) making linearized trees (reestimating branch lengths under the assumption of constant rate of evolutions. The data that can be used are nucleotide or amino acid sequences.

For details of the methods, please look at "Phylogenetic tests of the molecular clock and linearized trees" by Naoko Takezaki, Andrey Rzhetsky, and Masatoshi Nei ( Molecular Biology and Evolution 12:823-833, 1995 ).