Immunology

Staff

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Current Research Projects

Dendritic cell group
  • Analysis of the functional molecules which regulate production of type I interferons in plasmacytoid dendritic cells.
  • Study of the mechanisms regulating the function of the dendritic cell subsets.
Galectin-9 group
  • An endogenous lectin galectin-9 has been known to exert various immunomodulatory functions, which now comes to attract broader attention in medical field as one of the important player of immune-checkpoint. Our objective is to elucidate the molecular mechanism of galectin-9 in ameliorating skewed immune balance, and to explore potential therapeutic utility of the lectin for the treatment of refractory diseases including cancer and autoimmunity.

Selected Publications

Dendritic cell group
  • Immunomodulatory effects of D-allose on cytokine production by plasmacytoid dendritic cells.
    Takao, K., et al. Biochem Biophys Res Commun 627, 130-136 (2022)
  • Transcription factor MafB-mediated inhibition of type I interferons in plasmacytoid dendritic cells.
    Saiga, H., et al. Int Immunol 34(3), 159-172 (2022).
  • The mechanism of action of Spi-B in the transcriptional activation of the interferon-alpha4 gene.
    Miyazaki, R., et al. Biochem Biophys Res Commun 525(2), 477-482 (2020).

Recent Publications

Galectin-9 group
  • Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 infection
    ST Yeung, et al. Frontiers in immunology 13, 1011185 (2022)
  • Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity.
    Avtenyuk NU, et al. Biomedicines 10, 66 (2021).
  • Plasma Levels of a Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection.
    Padilla ST, et al. Biomolecules 10, 1495 (2020)

Contact Information

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